Liu Xiaoyu, Li Shangda, Yu Yueran, Hu Jianbo, Xu Yi
Department of Psychiatry, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
Department of Infectious Diseases, Tongde Hospital of Zhejiang Province, Hangzhou 310003, China.
Brain Sci. 2023 Jul 20;13(7):1096. doi: 10.3390/brainsci13071096.
Recent studies have shown that neuropeptides and neurotrophic factors may be involved in the pathophysiological mechanisms of suicide. However, the current research on this aspect is still insufficient. Our study aimed to explore the biological patterns of suicide deaths, including levels of BDNF, proBDNF, BDNF/proBDNF, Trk-b, GDNF, and TPH2. The researchers selected 25 normal control patients matched by age with 30 suicide deaths. We used enzyme-linked immunosorbent assays to detect the levels of BDNF, proBDNF, BDNF/proBDNF, Trk-b, GDNF, and TPH2 in the plasma of suicide and control subjects. proBDNF, BDNF/proBDNF, Trk-b, GDNF, and TPH2 levels are shown as the median (25th-75th percentile). BDNF levels are shown as the mean (standard error of the mean). (1) The levels of plasma TPH2 and proBDNF in people who died by suicide were significantly higher than those in the control group. (2) The plasma levels of GDNF and BDNF/proBDNF in the suicide group were obviously lower than those in the control group. (3) There was no significant difference in plasma BDNF or Trk-b concentrations between the suicide group and the control group.Plasma TPH2, GDNF, and proBDNF levels are related to suicide. Plasma neurotrophic factor markers may predict suicide risk.
近期研究表明，神经肽和神经营养因子可能参与自杀的病理生理机制。然而，目前这方面的研究仍不充分。我们的研究旨在探索自杀死亡的生物学模式，包括脑源性神经营养因子（BDNF）、前体BDNF、BDNF/前体BDNF、酪氨酸激酶受体B（Trk-b）、胶质细胞源性神经营养因子（GDNF）和色氨酸羟化酶2（TPH2）的水平。研究人员选取了25名年龄匹配的正常对照患者和30例自杀死亡者。我们采用酶联免疫吸附测定法检测自杀组和对照组受试者血浆中BDNF、前体BDNF、BDNF/前体BDNF、Trk-b、GDNF和TPH2的水平。前体BDNF、BDNF/前体BDNF、Trk-b、GDNF和TPH2水平以中位数（第25至75百分位数）表示。BDNF水平以均值（均值标准误）表示。（1）自杀死亡者血浆中TPH2和前体BDNF水平显著高于对照组。（2）自杀组血浆中GDNF和BDNF/前体BDNF水平明显低于对照组。（3）自杀组与对照组血浆中BDNF或Trk-b浓度无显著差异。血浆TPH2、GDNF和前体BDNF水平与自杀有关。血浆神经营养因子标志物可能预测自杀风险。
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