Kim Eun Kyung, Koo Ja Seung
Department of Pathology, National Health Insurance Service Ilsan Hospital, Goyang 10444, Republic of Korea.
Department of Pathology, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.
Biomedicines. 2023 Jul 4;11(7):1896. doi: 10.3390/biomedicines11071896.
We delved into the expression of amine oxidase family proteins and their potential significance in adrenal gland neoplasm. Tissue microarrays were prepared for 132 cases of adrenal cortical neoplasm (ACN) consisting of 115 cases of adrenal cortical adenoma (ACA), 17 cases of adrenal cortical carcinoma (ACC), and 163 cases of pheochromocytoma (PCC). Immunohistochemical stainings for MAOA, MAOB, LOX, and AOC3 were performed to evaluate the H-scores and compare them with clinicopathological parameters. The H-scores of MAOA (T; = 0.005) and MAOB (T; = 0.006) in tumor cells (T) were high in ACN, whereas LOX (T, S; < 0.001) in tumor and stromal cells (S) and AOC3 (T; < 0.001) were higher in PCC. In stromal cells, MAOA (S; < 0.001) and AOC3 (S; = 0.010) were more expressed in ACA than in ACC. MAOB (S) in PCC showed higher H-scores when the grading of adrenal pheochromocytoma and paraganglioma (GAPP) score was 3 or higher ( = 0.027). In the univariate analysis, low MAOA expression in stromal cells of ACN was associated with shorter overall survival ( = 0.008). In conclusion, monoamine oxidase proteins revealed differences in expression between ACN and PCC and also between benign and malignant cells.
我们深入研究了胺氧化酶家族蛋白的表达及其在肾上腺肿瘤中的潜在意义。为132例肾上腺皮质肿瘤（ACN）制备了组织微阵列，其中包括115例肾上腺皮质腺瘤（ACA）、17例肾上腺皮质癌（ACC）和163例嗜铬细胞瘤（PCC）。对MAOA、MAOB、LOX和AOC3进行免疫组织化学染色以评估H评分，并将其与临床病理参数进行比较。ACN中肿瘤细胞（T）的MAOA（T； = 0.005）和MAOB（T； = 0.006）的H评分较高，而肿瘤和基质细胞（S）中的LOX（T，S； < 0.001）和PCC中的AOC3（T； < 0.001）更高。在基质细胞中，ACA中MAOA（S； < 0.001）和AOC3（S； = 0.010）的表达高于ACC。当肾上腺嗜铬细胞瘤和副神经节瘤（GAPP）评分为3或更高时，PCC中的MAOB（S）显示出更高的H评分（ = 0.027）。在单变量分析中，ACN基质细胞中MAOA低表达与总生存期较短相关（ = 0.008）。总之，单胺氧化酶蛋白在ACN和PCC之间以及良性和恶性细胞之间的表达存在差异。
