Lu Yan-Ting, Lin Chih-Hsiang, Ho Chen-Jui, Chen Shih-Ying, Tsai Meng-Han
Department of Neurology, Kaohsiung Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Kaohsiung 833401, Taiwan.
College of Medicine, Medical School, Chang Gung University, Taoyuan 333323, Taiwan.
Biomedicines. 2023 Jul 5;11(7):1906. doi: 10.3390/biomedicines11071906.
Autoimmune encephalitis (AE) is a neurological emergency. We aimed to analyze the application and effectiveness of the currently available prediction tools for AE patients in Taiwan. We retrospectively collected 27 AE patients between January 2008 and December 2019. Antibody Prevalence in Epilepsy (APE) score, Response to Immunotherapy in Epilepsy (RITE) score, and anti-NMDAR Encephalitis One Year Functional Status (NEOS) score were applied to validate their usability. Based on the defined cutoff values, the sensitivity and specificity of each score were calculated. A receiver operating characteristic (ROC) curve and the area under the curve (AUC) were generated for each scoring system. The AUC value of APE was 0.571. The AUC value of RITE was 0.550. The AUC values for the NEOS score at discharge and long-term follow-up were 0.645 and 0.796, respectively. The performance of APE and RITE scores was suboptimal in the Taiwanese cohort, probably due to the limitations of the small sample size and single ethnicity. On the other hand, the NEOS score performed better on long-term follow-up than at discharge.
自身免疫性脑炎（AE）是一种神经系统急症。我们旨在分析台湾地区目前可用的AE患者预测工具的应用情况及有效性。我们回顾性收集了2008年1月至2019年12月期间的27例AE患者。应用癫痫抗体患病率（APE）评分、癫痫免疫治疗反应（RITE）评分以及抗NMDAR脑炎一年功能状态（NEOS）评分来验证其可用性。根据定义的临界值，计算每个评分的敏感性和特异性。为每个评分系统绘制了受试者工作特征（ROC）曲线及曲线下面积（AUC）。APE的AUC值为0.571。RITE的AUC值为0.550。出院时和长期随访时NEOS评分的AUC值分别为0.645和0.796。在台湾队列中，APE和RITE评分的表现欠佳，可能是由于样本量小和种族单一的局限性。另一方面，NEOS评分在长期随访中的表现优于出院时。
