Hu Qianjiang, Saleem Komal, Pandey Jyotsana, Charania Arzoo N, Zhou Yong, He Chao
Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Biomedicines. 2023 Jul 14;11(7):1995. doi: 10.3390/biomedicines11071995.
Mechanisms underlying the pathogenesis of tissue fibrosis remain incompletely understood. Emerging evidence suggests that cell adhesion molecules (CAMs) are critical in fibrotic progression in many organs, including lung, kidney, skin, and liver. CAMs promote cell-cell and cell-extracellular matrix (ECM) interactions to maintain tissue architecture and normal function in homeostasis. However, dysregulated expression and function of CAMs can lead to chronic inflammation and tissue fibrosis. The major families of CAMs include integrins, cadherins, selectins, and immunoglobulins. Here, we review the role of the CAMs in fibrosis development across various organs with a focus on integrins and cadherins, and discuss their respective roles in the development of pulmonary fibrosis.
组织纤维化发病机制的潜在机制仍未完全明确。新出现的证据表明，细胞黏附分子（CAMs）在包括肺、肾、皮肤和肝脏在内的许多器官的纤维化进展中起关键作用。CAMs促进细胞间和细胞与细胞外基质（ECM）的相互作用，以维持组织架构和内环境稳态中的正常功能。然而，CAMs表达和功能失调可导致慢性炎症和组织纤维化。CAMs的主要家族包括整合素、钙黏蛋白、选择素和免疫球蛋白。在此，我们综述CAMs在各器官纤维化发展中的作用，重点关注整合素和钙黏蛋白，并讨论它们在肺纤维化发展中的各自作用。
Zotero 插件