Faghfoori Zeinab, Javadivala Zeinab, Malek Mahdavi Aida
Food Safety Research Center (salt), Semnan University of Medical Sciences, Semnan, Iran.
Department of Nutrition, School of Nutrition and Food Sciences, Semnan University of Medical Sciences, Semnan, Iran.
J Cardiovasc Thorac Res. 2025 Mar 18;17(1):12-19. doi: 10.34172/jcvtr.025.33343. eCollection 2025 Mar.
The objective of present review was to assess all studies about effect of () on vascular cell and intercellular adhesion molecules-1 (VCAM-1 and ICAM-1) under different situations. Search was performed until May 2024 using Scopus, PubMed, Web of Science, and Google Scholar databases without any restriction and alert services were utilized following the primary search. The references cited in related papers were also evaluated. Nineteen studies including human (n=4), animal (n=11), and (n=4) were eligible. All and majority of animal researches were indicative of the favorable effects of and thymoquinone in attenuating VCAM-1 and ICAM-1 levels; however, three animal studies did not show any significant effect. Results of clinical trials were conflicting. In two clinical trials, supplementation with oil and powder led to significant reduction in VCAM-1 levels in coronary artery disease (CAD) and Hashimoto's thyroiditis patients, whereas no significant change occurred according to the other clinical trial involving subjects with the risk factor for cardiovascular disease (CVD). Furthermore, significant reduction in ICAM-1 levels occurred after oil consumption in two clinical trials involving type 2 diabetic and CAD patients, whilst no significant change was noticed in subjects with the risk factor for CVD and Hashimoto's thyroiditis patients. seems beneficial in attenuating VCAM-1 and ICAM-1 levels under different situations; however, additional long-term controlled clinical trials are needed for making concise conclusions about the effect of on endothelial dysfunction related biomarkers.
本综述的目的是评估在不同情况下关于（）对血管细胞和细胞间黏附分子-1（VCAM-1和ICAM-1）影响的所有研究。检索工作持续到2024年5月，使用Scopus、PubMed、Web of Science和谷歌学术数据库，无任何限制，并在初步检索后利用了提醒服务。还评估了相关论文中引用的参考文献。19项研究符合条件，包括人体研究（n = 4）、动物研究（n = 11）和（n = 4）。所有动物研究以及大多数动物研究均表明（）和百里醌在降低VCAM-1和ICAM-1水平方面具有有益作用；然而，三项动物研究未显示出任何显著效果。临床试验结果相互矛盾。在两项临床试验中，补充（）油和（）粉可使冠心病（CAD）和桥本甲状腺炎患者的VCAM-1水平显著降低，而在另一项涉及心血管疾病（CVD）危险因素受试者的临床试验中未发生显著变化。此外，在两项涉及2型糖尿病和CAD患者的临床试验中，食用（）油后ICAM-1水平显著降低，而在CVD危险因素受试者和桥本甲状腺炎患者中未发现显著变化。（）似乎在不同情况下对降低VCAM-1和ICAM-1水平有益；然而，需要更多长期对照临床试验才能对（）对内皮功能障碍相关生物标志物的影响得出确切结论。
