Goldilocks and the Three Trials: Clinical Trials Targeting the αβ Integrin in Idiopathic Pulmonary Fibrosis.
作者信息
Sime Patricia, Jenkins Gisli
机构信息
Virginia Commonwealth University Health System Richmond, Virginia.
National Heart and Lung Institute Imperial College London London, United Kingdom.
出版信息
Am J Respir Crit Care Med. 2022 Nov 1;206(9):1062-1063. doi: 10.1164/rccm.202208-1579ED.
Abstract
摘要
相似文献
1
Goldilocks and the Three Trials: Clinical Trials Targeting the αβ Integrin in Idiopathic Pulmonary Fibrosis.金发姑娘与三项试验：针对特发性肺纤维化中αβ整合素的临床试验
Am J Respir Crit Care Med. 2022 Nov 1;206(9):1062-1063. doi: 10.1164/rccm.202208-1579ED.
2
Amplification of TGFβ Induced ITGB6 Gene Transcription May Promote Pulmonary Fibrosis.转化生长因子β诱导的整合素β6基因转录扩增可能促进肺纤维化。
PLoS One. 2016 Aug 5;11(8):e0158047. doi: 10.1371/journal.pone.0158047. eCollection 2016.
3
Preclinical SPECT/CT imaging of αvβ6 integrins for molecular stratification of idiopathic pulmonary fibrosis.αvβ6 整联蛋白的临床前 SPECT/CT 成像用于特发性肺纤维化的分子分层。
J Nucl Med. 2013 Dec;54(12):2146-52. doi: 10.2967/jnumed.113.120592. Epub 2013 Oct 28.
4
Dual inhibition of αβ and αβ reduces fibrogenesis in lung tissue explants from patients with IPF.双重抑制 αβ 和 αβ 可减少 IPF 患者肺组织外植体中的纤维化。
Respir Res. 2021 Oct 19;22(1):265. doi: 10.1186/s12931-021-01863-0.
5
A positron emission tomography imaging study to confirm target engagement in the lungs of patients with idiopathic pulmonary fibrosis following a single dose of a novel inhaled αvβ6 integrin inhibitor.一项正电子发射断层扫描成像研究，旨在确认新型吸入型 αvβ6 整联蛋白抑制剂单次给药后特发性肺纤维化患者肺部的靶标占有率。
Respir Res. 2020 Mar 26;21(1):75. doi: 10.1186/s12931-020-01339-7.
6
Translational pharmacology of an inhaled small molecule αvβ6 integrin inhibitor for idiopathic pulmonary fibrosis.一种用于特发性肺纤维化的吸入型小分子αvβ6整合素抑制剂的转化药理学
Nat Commun. 2020 Sep 16;11(1):4659. doi: 10.1038/s41467-020-18397-6.
7
Inhibition of integrin αvβ6 sparks T-cell antitumor response and enhances immune checkpoint blockade therapy in colorectal cancer.整合素 αvβ6 的抑制作用激发了 T 细胞抗肿瘤反应，并增强了结直肠癌的免疫检查点阻断治疗。
J Immunother Cancer. 2022 Feb;10(2). doi: 10.1136/jitc-2021-003465.
8
Discovery of ( S)-3-(3-(3,5-Dimethyl-1 H-pyrazol-1-yl)phenyl)-4-(( R)-3-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)pyrrolidin-1-yl)butanoic Acid, a Nonpeptidic αβ Integrin Inhibitor for the Inhaled Treatment of Idiopathic Pulmonary Fibrosis.发现（S）-3-（3-（3,5-二甲基-1 H-吡唑-1-基）苯基）-4-（（R）-3-（2-（5,6,7,8-四氢-1,8-萘啶-2-基）乙基）吡咯烷-1-基）丁酸，一种用于治疗特发性肺纤维化的吸入用非肽类αβ整合素抑制剂。
J Med Chem. 2018 Sep 27;61(18):8417-8443. doi: 10.1021/acs.jmedchem.8b00959. Epub 2018 Sep 14.
9
Randomized Phase IIa Clinical Study of an Anti-αβ Monoclonal Antibody in Idiopathic Pulmonary Fibrosis.抗αβ单克隆抗体治疗特发性肺纤维化的随机IIa期临床研究
Am J Respir Crit Care Med. 2022 Nov 1;206(9):1166-1168. doi: 10.1164/rccm.202205-0868LE.
10
Synthesis and determination of absolute configuration of a non-peptidic αvβ6 integrin antagonist for the treatment of idiopathic pulmonary fibrosis.用于治疗特发性肺纤维化的非肽类αvβ6整合素拮抗剂的合成及绝对构型测定
Org Biomol Chem. 2016 Jul 7;14(25):5992-6009. doi: 10.1039/c6ob00496b. Epub 2016 May 26.
引用本文的文献
1
The fibrosis puzzle of systemic sclerosis-associated ILD and the quest for targeted interventions.系统性硬化症相关间质性肺病的纤维化难题与靶向干预探索
Ther Adv Respir Dis. 2025 Jan-Dec;19:17534666251366023. doi: 10.1177/17534666251366023. Epub 2025 Aug 16.
2
Multi-omic and Single-Cell Approaches for Elucidating Cell Biology and Pathobiology of Lung Disease.用于阐明肺部疾病细胞生物学和病理生物学的多组学和单细胞方法
Am J Respir Cell Mol Biol. 2025 Jul 23. doi: 10.1165/rcmb.2025-0092PS.
3
Therapeutic Prospects of αv Integrins Inhibition in Fibrotic Lung Diseases and Carcinogenesis.αv整合素抑制在纤维化肺病和癌症发生中的治疗前景
Int J Mol Sci. 2025 Jun 27;26(13):6202. doi: 10.3390/ijms26136202.
4
Novel high throughput 3D ECM remodeling assay identifies MEK as key driver of fibrotic fibroblast activity.新型高通量3D细胞外基质重塑检测法确定MEK是纤维化成纤维细胞活性的关键驱动因素。
Mater Today Bio. 2025 Apr 24;32:101800. doi: 10.1016/j.mtbio.2025.101800. eCollection 2025 Jun.
5
Advances in idiopathic pulmonary fibrosis diagnosis and treatment.特发性肺纤维化诊断与治疗的进展
Chin Med J Pulm Crit Care Med. 2025 Mar 7;3(1):12-21. doi: 10.1016/j.pccm.2025.02.001. eCollection 2025 Mar.
6
Pulmonary fibroelastosis - A review.肺弹力纤维增生症——综述。
Matrix Biol. 2023 Dec;124:1-7. doi: 10.1016/j.matbio.2023.10.003. Epub 2023 Nov 3.
7
De novo design of highly selective miniprotein inhibitors of integrins αvβ6 and αvβ8.从头设计高选择性整合素 αvβ6 和 αvβ8 的小分子抑制剂。
Nat Commun. 2023 Sep 13;14(1):5660. doi: 10.1038/s41467-023-41272-z.
8
Cell Adhesion Molecules in Fibrotic Diseases.纤维化疾病中的细胞黏附分子
Biomedicines. 2023 Jul 14;11(7):1995. doi: 10.3390/biomedicines11071995.
9
design of highly selective miniprotein inhibitors of integrins αvβ6 and αvβ8.整合素αvβ6和αvβ8的高选择性微型蛋白抑制剂的设计
bioRxiv. 2023 Jun 12:2023.06.12.544624. doi: 10.1101/2023.06.12.544624.
本文引用的文献
1
Randomized Phase IIa Clinical Study of an Anti-αβ Monoclonal Antibody in Idiopathic Pulmonary Fibrosis.抗αβ单克隆抗体治疗特发性肺纤维化的随机IIa期临床研究
Am J Respir Crit Care Med. 2022 Nov 1;206(9):1166-1168. doi: 10.1164/rccm.202205-0868LE.
2
A Phase IIb Randomized Clinical Study of an Anti-αβ Monoclonal Antibody in Idiopathic Pulmonary Fibrosis.一项抗 αβ 单克隆抗体治疗特发性肺纤维化的 IIb 期随机临床试验。
Am J Respir Crit Care Med. 2022 Nov 1;206(9):1128-1139. doi: 10.1164/rccm.202112-2824OC.
3
Translational pharmacology of an inhaled small molecule αvβ6 integrin inhibitor for idiopathic pulmonary fibrosis.一种用于特发性肺纤维化的吸入型小分子αvβ6整合素抑制剂的转化药理学
Nat Commun. 2020 Sep 16;11(1):4659. doi: 10.1038/s41467-020-18397-6.
4
A Potent Pan-TGFβ Neutralizing Monoclonal Antibody Elicits Cardiovascular Toxicity in Mice and Cynomolgus Monkeys.一种强效的泛 TGFβ 中和单克隆抗体可在小鼠和食蟹猴中引起心血管毒性。
Toxicol Sci. 2020 May 1;175(1):24-34. doi: 10.1093/toxsci/kfaa024.
5
Integrin αvβ6: Structure, function and role in health and disease.整合素 αvβ6：结构、功能及其在健康和疾病中的作用。
Int J Biochem Cell Biol. 2018 Jun;99:186-196. doi: 10.1016/j.biocel.2018.04.013. Epub 2018 Apr 18.
6
The αvβ1 integrin plays a critical in vivo role in tissue fibrosis.αvβ1整合素在组织纤维化的体内过程中发挥着关键作用。
Sci Transl Med. 2015 May 20;7(288):288ra79. doi: 10.1126/scitranslmed.aaa5094.
7
αvβ6 integrin may be a potential prognostic biomarker in interstitial lung disease.αvβ6 整合素可能是间质性肺疾病的一个潜在预后生物标志物。
Eur Respir J. 2015 Aug;46(2):486-94. doi: 10.1183/09031936.00210414. Epub 2015 Mar 5.
8
Partial inhibition of integrin alpha(v)beta6 prevents pulmonary fibrosis without exacerbating inflammation.整合素α(v)β6的部分抑制可预防肺纤维化而不加重炎症。
Am J Respir Crit Care Med. 2008 Jan 1;177(1):56-65. doi: 10.1164/rccm.200706-805OC. Epub 2007 Oct 4.
9
Integrin beta6 mediates phospholipid and collectin homeostasis by activation of latent TGF-beta1.整合素β6通过激活潜伏的转化生长因子β1介导磷脂和凝集素稳态。
Am J Respir Cell Mol Biol. 2007 Dec;37(6):651-9. doi: 10.1165/rcmb.2006-0428OC. Epub 2007 Jul 19.
10
Loss of integrin alpha(v)beta6-mediated TGF-beta activation causes Mmp12-dependent emphysema.整合素α(v)β6介导的转化生长因子-β激活缺失导致依赖基质金属蛋白酶12的肺气肿。
Nature. 2003 Mar 13;422(6928):169-73. doi: 10.1038/nature01413.
Zotero 插件