Department of Health and Biomedical Science, College of Health Affairs, University of Texas Rio Grande Valley, Edinburg, TX 78539, USA.
Department of Science, Graduate College of Biochemistry and Molecular Biology, University of Texas Rio Grande Valley, Edinburg, TX 78539, USA.
Genes (Basel). 2023 Jul 6;14(7):1405. doi: 10.3390/genes14071405.
Alzheimer's disease (AD), a main cause of dementia, is commonly seen in aging populations with a strong genetic component. AD is one of the most common neurodegenerative disorders; it is a genetically and clinically heterogeneous disease. Specific demographic factors and genetic variants have been identified in non-Hispanic populations; however, limited studies have observed the Hispanic population. Therefore, we focused on investigating a known gene, APOE, associated with AD-related phenotypes and two psychiatric diseases (depression and anxiety) within the U.S. Hispanic population in our current study. A total of 1382 subjects were studied based on data collected from the Texas Alzheimer's Research and Care Consortium (TARCC, = 1320) and the Initial Study of Longevity and Dementia from the Rio Grande Valley (ISLD-RGV, = 62). Questionnaires regarding demographics, medical history, and blood/saliva samples were collected. We genotyped the APOE gene. The current findings indicated that APOE-ε4 was associated with not only AD ( < 0.0001) but also with anxiety ( < 0.0001) and depression ( = 0.0004). However, APOE-ε3 was associated with depression ( = 0.002) in the Hispanic population. We provide additional evidence in which APOE-ε4 increased the risk for AD in Hispanics. For the first time, APOE alleles show increased risks for anxiety and depression in Hispanics. Further research is warranted to confirm the current findings.
阿尔茨海默病（AD）是一种主要的痴呆症，常见于老龄化人群，具有很强的遗传成分。AD 是最常见的神经退行性疾病之一；它是一种具有遗传和临床异质性的疾病。在非西班牙裔人群中已经确定了特定的人口统计学因素和遗传变异；然而，对西班牙裔人群的研究有限。因此，我们在本研究中专注于研究在美国西班牙裔人群中与 AD 相关表型和两种精神疾病（抑郁和焦虑）相关的已知基因 APOE。共有 1382 名受试者根据德克萨斯州阿尔茨海默病研究和护理联合会（TARCC，n = 1320）和格兰德河谷长寿和痴呆症初始研究（ISLD-RGV，n = 62）收集的数据进行研究。收集了有关人口统计学、病史和血液/唾液样本的问卷。我们对 APOE 基因进行了基因分型。目前的研究结果表明，APOE-ε4 不仅与 AD 相关（<0.0001），还与焦虑（<0.0001）和抑郁（=0.0004）相关。然而，APOE-ε3 与西班牙裔人群的抑郁相关（=0.002）。我们提供了额外的证据，表明 APOE-ε4 增加了西班牙裔人群患 AD 的风险。首次表明 APOE 等位基因增加了西班牙裔人群患焦虑和抑郁的风险。需要进一步的研究来证实目前的研究结果。
