• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

中性力量与平衡选择相互作用塑造内蒙古仓鼠主要组织相容性复合体空间模式：暗示广泛的局部适应。

Neutral Forces and Balancing Selection Interplay to Shape the Major Histocompatibility Complex Spatial Patterns in the Striped Hamster in Inner Mongolia: Suggestive of Broad-Scale Local Adaptation.

机构信息

National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.

School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, China.

出版信息

Genes (Basel). 2023 Jul 22;14(7):1500. doi: 10.3390/genes14071500.

DOI:10.3390/genes14071500
PMID:37510404
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10379431/
Abstract

BACKGROUND

The major histocompatibility complex (MHC) plays a key role in the adaptive immune response to pathogens due to its extraordinary polymorphism. However, the spatial patterns of MHC variation in the striped hamster remain unclear, particularly regarding the relative contribution of the balancing selection in shaping MHC spatial variation and diversity compared to neutral forces.

METHODS

In this study, we investigated the immunogenic variation of the striped hamster in four wild populations in Inner Mongolia which experience a heterogeneous parasitic burden. Our goal was to identify local adaptation by comparing the genetic structure at the MHC with that at seven microsatellite loci, taking into account neutral processes.

RESULTS

We observed significant variation in parasite pressure among sites, with parasite burden showing a correlation with temperature and precipitation. Molecular analysis revealed a similar co-structure between MHC and microsatellite loci. We observed lower genetic differentiation at MHC loci compared to microsatellite loci, and no correlation was found between the two.

CONCLUSIONS

Overall, these results suggest a complex interplay between neutral evolutionary forces and balancing selection in shaping the spatial patterns of MHC variation. Local adaptation was not detected on a small scale but may be applicable on a larger scale.

摘要

背景

主要组织相容性复合体（MHC）因其极高的多态性，在病原体的适应性免疫反应中起着关键作用。然而，条纹仓鼠 MHC 变异的空间模式仍不清楚，特别是在平衡选择相对于中性力量塑造 MHC 空间变异和多样性方面的相对贡献。

方法

本研究在内蒙古的四个野生种群中调查了条纹仓鼠的免疫原性变异，这些种群经历着不均匀的寄生虫负担。我们的目标是通过比较 MHC 与七个微卫星位点的遗传结构，同时考虑中性过程，来识别局部适应。

结果

我们观察到不同地点的寄生虫压力存在显著差异，寄生虫负担与温度和降水呈正相关。分子分析表明 MHC 和微卫星位点之间存在相似的共结构。我们观察到 MHC 基因座的遗传分化程度低于微卫星基因座，并且两者之间没有相关性。

结论

总体而言，这些结果表明中性进化力量和平衡选择在塑造 MHC 变异的空间模式方面存在复杂的相互作用。在小范围内没有检测到局部适应，但在更大范围内可能适用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e9f/10379431/e2e0da974048/genes-14-01500-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e9f/10379431/12deea906f2c/genes-14-01500-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e9f/10379431/593f86a968e5/genes-14-01500-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e9f/10379431/f53338822680/genes-14-01500-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e9f/10379431/72842b314eeb/genes-14-01500-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e9f/10379431/dc5c32427d6d/genes-14-01500-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e9f/10379431/e2e0da974048/genes-14-01500-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e9f/10379431/12deea906f2c/genes-14-01500-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e9f/10379431/593f86a968e5/genes-14-01500-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e9f/10379431/f53338822680/genes-14-01500-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e9f/10379431/72842b314eeb/genes-14-01500-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e9f/10379431/dc5c32427d6d/genes-14-01500-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e9f/10379431/e2e0da974048/genes-14-01500-g006.jpg

相似文献

1
Neutral Forces and Balancing Selection Interplay to Shape the Major Histocompatibility Complex Spatial Patterns in the Striped Hamster in Inner Mongolia: Suggestive of Broad-Scale Local Adaptation.中性力量与平衡选择相互作用塑造内蒙古仓鼠主要组织相容性复合体空间模式：暗示广泛的局部适应。
Genes (Basel). 2023 Jul 22;14(7):1500. doi: 10.3390/genes14071500.
2
Balancing selection and genetic drift at major histocompatibility complex class II genes in isolated populations of golden snub-nosed monkey (Rhinopithecus roxellana).平衡选择和遗传漂变在孤立的金丝猴（Rhinopithecus roxellana）种群主要组织相容性复合体 II 基因。
BMC Evol Biol. 2012 Oct 19;12:207. doi: 10.1186/1471-2148-12-207.
3
Lack of Spatial Immunogenetic Structure among Wolverine (Gulo gulo) Populations Suggestive of Broad Scale Balancing Selection.狼獾（貂熊属貂熊种）种群间缺乏空间免疫遗传结构，提示存在广泛的平衡选择。
PLoS One. 2015 Oct 8;10(10):e0140170. doi: 10.1371/journal.pone.0140170. eCollection 2015.
4
On the relative roles of selection and genetic drift in shaping MHC variation.在塑造 MHC 变异中选择和遗传漂变的相对作用。
Mol Ecol. 2010 Sep;19(18):3842-4. doi: 10.1111/j.1365-294X.2010.04772.x.
5
Parasite-mediated selection of major histocompatibility complex variability in wild brandt's voles (Lasiopodomys brandtii) from Inner Mongolia, China.寄生虫在中国内蒙古布氏田鼠（Lasiopodomys brandtii）中对主要组织相容性复合体变异性的介导选择。
BMC Evol Biol. 2013 Jul 12;13:149. doi: 10.1186/1471-2148-13-149.
6
Spatio-temporal variation in the strength and mode of selection acting on major histocompatibility complex diversity in water vole (Arvicola terrestris) metapopulations.水田鼠（Arvicola terrestris）集合种群中，作用于主要组织相容性复合体多样性的选择强度和模式的时空变化。
Mol Ecol. 2009 Jan;18(1):80-92. doi: 10.1111/j.1365-294X.2008.04015.x.
7
Both selection and drift drive the spatial pattern of adaptive genetic variation in a wild mammal.选择和漂变都驱动了野生哺乳动物适应性遗传变异的空间模式。
Evolution. 2023 Jan 23;77(1):221-238. doi: 10.1093/evolut/qpac014.
8
Selection outweighs drift at a fine scale: Lack of MHC differentiation within a family living lizard across geographically close but disconnected rocky outcrops.在精细尺度上，选择胜过漂变：生活在地理上接近但不相连的岩石露头的一个蜥蜴家族内缺乏 MHC 分化。
Mol Ecol. 2018 May;27(9):2204-2214. doi: 10.1111/mec.14571. Epub 2018 Apr 20.
9
Very high MHC Class IIB diversity without spatial differentiation in the mediterranean population of greater Flamingos.大凤头鹈鹕地中海种群的 MHC Ⅱ B 类高度多样性，无空间分化。
BMC Evol Biol. 2017 Feb 20;17(1):56. doi: 10.1186/s12862-017-0905-3.
10
Allelic diversity and patterns of selection at the major histocompatibility complex class I and II loci in a threatened shorebird, the Snowy Plover (Charadrius nivosus).在受威胁的滨鸟——雪鹱（Charadrius nivosus）中，主要组织相容性复合体 I 类和 II 类基因座的等位基因多样性和选择模式。
BMC Evol Biol. 2020 Sep 10;20(1):114. doi: 10.1186/s12862-020-01676-7.

引用本文的文献

1
Effects of individual characteristics and seasonality and their interaction on ectoparasite load of Daurian ground squirrels in Inner Mongolia, China.个体特征、季节性及其相互作用对中国内蒙古达乌尔黄鼠体表寄生虫负荷的影响。
Int J Parasitol Parasites Wildl. 2024 Nov 2;25:101014. doi: 10.1016/j.ijppaw.2024.101014. eCollection 2024 Dec.
2
Exploring genetic diversity and variation of Ovar-DRB1 gene in Sudan Desert Sheep using targeted next-generation sequencing.利用靶向下一代测序技术探索苏丹沙漠绵羊 Ovar-DRB1 基因的遗传多样性和变异。
BMC Genomics. 2024 Feb 8;25(1):160. doi: 10.1186/s12864-024-10053-3.

本文引用的文献

1
Both selection and drift drive the spatial pattern of adaptive genetic variation in a wild mammal.选择和漂变都驱动了野生哺乳动物适应性遗传变异的空间模式。
Evolution. 2023 Jan 23;77(1):221-238. doi: 10.1093/evolut/qpac014.
2
Potential Effects of Environmental Conditions on Prairie Dog Flea Development and Implications for Sylvatic Plague Epizootics.环境条件对草原犬蚤发育的潜在影响及其对森林鼠疫流行的意义。
Ecohealth. 2022 Sep;19(3):365-377. doi: 10.1007/s10393-022-01615-6. Epub 2022 Sep 20.
3
Divergent and non-parallel evolution of MHC IIB in the Neotropical Midas cichlid species complex.
新热带慈鲷米亚达鱼物种复合体中 MHC IIB 的趋异和非平行进化。
BMC Ecol Evol. 2022 Apr 1;22(1):41. doi: 10.1186/s12862-022-01997-9.
4
Neutral and Selective Processes Shape MHC Diversity in Roe Deer in Slovenia.中性和选择性过程塑造了斯洛文尼亚狍的主要组织相容性复合体多样性。
Animals (Basel). 2022 Mar 13;12(6):723. doi: 10.3390/ani12060723.
5
Infestation and Seasonal Fluctuation of Gamasid Mites (Parasitiformes: Gamasida) on Indochinese Forest Rat, (Rodentia: Muridae) in Southern Yunnan of China.中国云南南部印支林鼠（啮齿目：鼠科）体表革螨（寄螨目：革螨亚目）的寄生情况及季节消长
Biology (Basel). 2021 Dec 8;10(12):1297. doi: 10.3390/biology10121297.
6
Why do parasites exhibit reverse latitudinal diversity gradients? Testing the roles of host diversity, habitat and climate.为什么寄生虫呈现出反向纬度多样性梯度？检验宿主多样性、栖息地和气候的作用。
Glob Ecol Biogeogr. 2021 Sep;30(9):1810-1821. doi: 10.1111/geb.13347. Epub 2021 Jun 28.
7
Infection in Bank Voles Is Associated With Specific DQB Haplotypes Which Affect Allelic Divergence Within Individuals.在田鼠中，感染与特定的 DQB 单倍型相关，这些单倍型会影响个体内部的等位基因分歧。
Front Immunol. 2021 Jul 26;12:703025. doi: 10.3389/fimmu.2021.703025. eCollection 2021.
8
Genetic source tracking of human plague cases in Inner Mongolia-Beijing, 2019.2019 年内蒙古-北京人间鼠疫病例的遗传溯源。
PLoS Negl Trop Dis. 2021 Aug 3;15(8):e0009558. doi: 10.1371/journal.pntd.0009558. eCollection 2021 Aug.
9
What evolutionary processes maintain MHC IIꞵ diversity within and among populations of stickleback?刺鱼体内和群体间 MHC IIβ 多样性是如何维持的？进化过程在其中起到了什么作用？
Mol Ecol. 2021 Apr;30(7):1659-1671. doi: 10.1111/mec.15840. Epub 2021 Feb 25.
10
Climate change effects on biodiversity, ecosystems, ecosystem services, and natural resource management in the United States.气候变化对美国生物多样性、生态系统、生态系统服务和自然资源管理的影响。
Sci Total Environ. 2020 Sep 1;733:137782. doi: 10.1016/j.scitotenv.2020.137782. Epub 2020 Mar 10.