Rocans Rihards P, Zarins Janis, Bine Evita, Deksnis Renars, Citovica Margarita, Donina Simona, Mamaja Biruta
Intensive Care Clinic, Riga East Clinical University Hospital, Hipokrata Street 2, LV-1079 Riga, Latvia.
Department of Anaesthesia and Intensive Care, Riga Stradins University, Dzirciema Street 16, LV-1007 Riga, Latvia.
J Clin Med. 2023 Jul 20;12(14):4794. doi: 10.3390/jcm12144794.
Microvascular flap surgery is a widely acknowledged procedure for significant defect reconstruction. Multiple flap complication risk factors have been identified, yet there are limited data on laboratory biomarkers for the prediction of flap loss. The controlling nutritional status (CONUT) score has demonstrated good postoperative outcome assessment ability in diverse surgical populations. We aim to assess the predictive value of the CONUT score for complications in microvascular flap surgery. This prospective cohort study includes 72 adult patients undergoing elective microvascular flap surgery. Preoperative blood draws for analysis of full blood count, total plasma cholesterol, and albumin concentrations were collected on the day of surgery before crystalloid infusion. Postoperative data on flap complications and duration of hospitalization were obtained. The overall complication rate was 15.2%. True flap loss with vascular compromise occurred in 5.6%. No differences in flap complications were found between different areas of reconstruction, anatomical flap types, or indications for surgery. Obesity was more common in patients with flap complications ( = 0.01). The CONUT score had an AUC of 0.813 (0.659-0.967, = 0.012) for predicting complications other than true flap loss due to vascular compromise. A CONUT score > 2 was indicated as optimal during cut-off analysis ( = 0.022). Patients with flap complications had a longer duration of hospitalization (13.55, 10.99-16.11 vs. 25.38, 14.82-35.93; = 0.004). Our findings indicate that the CONUT score has considerable predictive value in microvascular flap surgery.
微血管皮瓣手术是一种被广泛认可的用于重大缺损重建的手术。已经确定了多种皮瓣并发症的危险因素,但关于预测皮瓣坏死的实验室生物标志物的数据有限。控制营养状态(CONUT)评分在不同手术人群中已显示出良好的术后结果评估能力。我们旨在评估CONUT评分对微血管皮瓣手术并发症的预测价值。这项前瞻性队列研究纳入了72例接受择期微血管皮瓣手术的成年患者。在手术当天晶体液输注前采集术前血样,用于分析全血细胞计数、总血浆胆固醇和白蛋白浓度。获取术后皮瓣并发症和住院时间的数据。总体并发症发生率为15.2%。因血管受损导致的真正皮瓣坏死发生率为5.6%。在不同的重建区域、解剖皮瓣类型或手术指征之间,皮瓣并发症没有差异。肥胖在皮瓣并发症患者中更为常见(P = 0.01)。CONUT评分预测除因血管受损导致的真正皮瓣坏死之外的并发症的AUC为0.813(0.659 - 0.967,P = 0.012)。在截断分析中,CONUT评分>2被认为是最佳截断值(P = 0.022)。有皮瓣并发症的患者住院时间更长(13.55,10.99 - 16.11对比25.38,14.82 - 35.93;P = 0.004)。我们的研究结果表明,CONUT评分在微血管皮瓣手术中具有相当大的预测价值。