Division of Endocrinology, Diabetes, Nutrition and Therapeutic Patient Education, Department of Medicine, Geneva University Hospitals, 1205 Geneva, Switzerland.
Diabetes Center, Faculty of Medicine, Geneva University, 1205 Geneva, Switzerland.
Int J Mol Sci. 2023 Jul 10;24(14):11271. doi: 10.3390/ijms241411271.
Nonalcoholic fatty liver disease (NAFLD) has become a widely studied subject due to its increasing prevalence and links to diseases such as type 2 diabetes and obesity. It has severe complications, including nonalcoholic steatohepatitis, cirrhosis, hepatocellular carcinoma, and portal hypertension that can lead to liver transplantation in some cases. To better prevent and treat this pathology, it is important to understand its underlying physiology. Here, we identify two main factors that play a crucial role in the pathophysiology of NAFLD: oxidative stress and the key role of carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1). We discuss the pathophysiology linking these factors to NAFLD pathophysiology.
非酒精性脂肪性肝病（NAFLD）因其发病率的增加以及与 2 型糖尿病和肥胖等疾病的关联而成为一个广泛研究的课题。它有严重的并发症，包括非酒精性脂肪性肝炎、肝硬化、肝细胞癌和门脉高压，在某些情况下可能导致肝移植。为了更好地预防和治疗这种病理，了解其潜在的生理学机制非常重要。在这里，我们确定了两个在 NAFLD 病理生理学中起关键作用的主要因素：氧化应激和癌胚抗原相关细胞黏附分子 1（CEACAM1）的关键作用。我们讨论了将这些因素与 NAFLD 病理生理学联系起来的病理生理学机制。
