Association of , , and Polymorphisms/Haplotypes with Susceptibility to and Clinical Manifestations of SLE.

Systemic lupus erythematosus (SLE) is characterized by an imbalance between proinflammatory and anti-inflammatory mediators. Single-nucleotide polymorphisms (SNPs) in genes coding , , and could affect their expression or function and disrupt immune homeostasis. We aimed to analyze the associations of , , and polymorphisms/haplotypes with patients' susceptibility to and clinical manifestations of SLE. Our study included 103 SLE patients and 99 healthy controls. The genotypes of the selected polymorphisms within (rs10892202, rs4252270, rs3135932, rs2228055, rs2229113, and rs9610), (rs999788, rs2834167, and rs1058867), and (rs3795299 and rs16829204) genes were determined by TaqMan Assays. rs1058867 G allele carriers were significantly more frequent among the controls than among the SLE patients (76.8% vs. 61.2%; = 0.017, OR = 0.477, 95% CI: 0.258-0.879). The CAA haplotype was more frequent among the SLE patients than in the control group (42.7% vs. 30.7%; = 0.027). The rs3795299 C allele and rs16829204 CC genotype were associated with Hashimoto thyroiditis in the SLE patients (n = 103; = 0.002 and = 0.026, respectively), and in all the included participants (n = 202, < 0.000 and = 0.007, respectively), and the CC haplotype was more frequent in the SLE patients with Hashimoto thyroiditis ( = 0.047) and in the overall participants with Hashimoto thyroiditis (n = 32, = 0.004). The , , and polymorphisms/haplotypes could be associated with SLE susceptibility and various clinical manifestations, and the CC haplotype could be associated with Hashimoto thyroiditis.