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胆固醇与脂蛋白代谢的新视角

New Perspectives on Cholesterol and Lipoprotein Metabolism.

机构信息

Centre for Molecular and Vascular Biology, Catholic University of Leuven, 3000 Leuven, Belgium.

出版信息

Int J Mol Sci. 2023 Jul 11;24(14):11298. doi: 10.3390/ijms241411298.

DOI:10.3390/ijms241411298
PMID:37511058
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10379683/
Abstract

In animals, cholesterol is an essential component of every cellular membrane and is required for cell membrane integrity [...].

摘要

在动物体内,胆固醇是每个细胞膜的重要组成部分,是维持细胞膜完整性所必需的。

相似文献

1
New Perspectives on Cholesterol and Lipoprotein Metabolism.胆固醇与脂蛋白代谢的新视角
Int J Mol Sci. 2023 Jul 11;24(14):11298. doi: 10.3390/ijms241411298.
2
How cells handle cholesterol.细胞如何处理胆固醇。
Science. 2000 Dec 1;290(5497):1721-6. doi: 10.1126/science.290.5497.1721.
3
Lipoprotein and cholesterol metabolism in rabbit arterial endothelial cells in culture.培养的兔动脉内皮细胞中的脂蛋白与胆固醇代谢
Biochim Biophys Acta. 1978 Jun 23;529(3):475-87. doi: 10.1016/0005-2760(78)90091-7.
4
Role of the liver in the degradation of lipoproteins.肝脏在脂蛋白降解中的作用。
Gastroenterology. 1985 Jan;88(1 Pt 1):192-205. doi: 10.1016/s0016-5085(85)80155-4.
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Effect of lipoproteins and altered lipid metabolism on the primary immune response in vitro.脂蛋白及脂质代谢改变对体外初次免疫应答的影响。
Curr Surg. 1980 Mar-Apr;37(2):136-40.
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Preparation of semisynthetic lipoproteins with fluorescent cholesterol anchor and their introduction to the cell membrane with minimal disruption of the membrane.半合成脂蛋白的制备,带有荧光胆固醇锚定,其引入细胞膜时对膜的破坏最小。
Bioconjug Chem. 2013 Oct 16;24(10):1684-97. doi: 10.1021/bc4002135. Epub 2013 Sep 24.
7
Lipoprotein receptors, plasma cholesterol metabolism, and the regulation of cellular free cholesterol concentration.脂蛋白受体、血浆胆固醇代谢与细胞游离胆固醇浓度的调节
FASEB J. 1992 Oct;6(13):3162-8. doi: 10.1096/fasebj.6.13.1327930.
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The exchange of unesterified cholesterol between human low-density lipoproteins and rat erythrocyte 'ghosts'.人低密度脂蛋白与大鼠红细胞“血影”之间未酯化胆固醇的交换
Biochem J. 1967 Jul;104(1):270-7. doi: 10.1042/bj1040270.
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Lipoproteins activate acyl-coenzyme A:cholesterol acyltransferase in macrophages only after cellular cholesterol pools are expanded to a critical threshold level.脂蛋白仅在细胞胆固醇池扩大到临界阈值水平后才会激活巨噬细胞中的酰基辅酶A:胆固醇酰基转移酶。
J Biol Chem. 1991 Sep 15;266(26):17040-8.
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Ionic channels and nerve membrane lipoproteins: DDT-nerve membrane interaction.离子通道与神经膜脂蛋白:滴滴涕与神经膜的相互作用。
Int J Neurosci. 1971 May;1(5):309-16. doi: 10.3109/00207457109147430.

本文引用的文献

1
Lathosterolosis: a rare cholesterol metabolism disorder with a wide range of clinical variability.羊毛甾醇血症:一种罕见的胆固醇代谢紊乱疾病,临床变异性广泛。
J Pediatr Endocrinol Metab. 2023 Jan 6;36(4):424-429. doi: 10.1515/jpem-2022-0586. Print 2023 Apr 25.
2
Effect of Lipid Raft Disruptors on Cell Membrane Fluidity Studied by Fluorescence Spectroscopy.荧光光谱法研究脂筏破坏剂对细胞膜流动性的影响。
Int J Mol Sci. 2022 Nov 8;23(22):13729. doi: 10.3390/ijms232213729.
3
Measurement of 7-dehydrocholesterol and cholesterol in hair can be used in the diagnosis of Smith-Lemli-Opitz syndrome.毛发中 7-脱氢胆固醇和胆固醇的测定可用于史密斯-林利-欧皮茨综合征的诊断。
J Lipid Res. 2022 Jun;63(6):100228. doi: 10.1016/j.jlr.2022.100228. Epub 2022 May 14.
4
Human Placental Intracellular Cholesterol Transport: A Focus on Lysosomal and Mitochondrial Dysfunction and Oxidative Stress.人胎盘细胞内胆固醇转运:聚焦于溶酶体和线粒体功能障碍及氧化应激
Antioxidants (Basel). 2022 Mar 4;11(3):500. doi: 10.3390/antiox11030500.
5
Role of high-density lipoproteins in cardioprotection and in reverse remodeling: Therapeutic implications.高密度脂蛋白在心脏保护和逆重构中的作用:治疗意义。
Biochim Biophys Acta Mol Cell Biol Lipids. 2021 Nov;1866(11):159022. doi: 10.1016/j.bbalip.2021.159022. Epub 2021 Jul 30.
6
High-Density Lipoprotein-Targeted Therapies for Heart Failure.针对心力衰竭的高密度脂蛋白靶向治疗
Biomedicines. 2020 Dec 16;8(12):620. doi: 10.3390/biomedicines8120620.
7
Rationale and design of ApoA-I Event Reducing in Ischemic Syndromes II (AEGIS-II): A phase 3, multicenter, double-blind, randomized, placebo-controlled, parallel-group study to investigate the efficacy and safety of CSL112 in subjects after acute myocardial infarction.载脂蛋白 A-I 减少缺血性综合征事件研究 II(AEGIS-II)的原理和设计:一项 3 期、多中心、双盲、随机、安慰剂对照、平行组研究,旨在评估 CSL112 在急性心肌梗死后患者中的疗效和安全性。
Am Heart J. 2021 Jan;231:121-127. doi: 10.1016/j.ahj.2020.10.052. Epub 2020 Oct 13.
8
Administration of apo A-I (Milano) nanoparticles reverses pathological remodelling, cardiac dysfunction, and heart failure in a murine model of HFpEF associated with hypertension.apo A-I(米兰)纳米颗粒给药可逆转与高血压相关的 HFpEF 小鼠模型中的病理性重塑、心功能障碍和心力衰竭。
Sci Rep. 2020 May 20;10(1):8382. doi: 10.1038/s41598-020-65255-y.
9
Hepatic stellate cell hypertrophy is associated with metabolic liver fibrosis.肝星状细胞肥大与代谢性肝纤维化有关。
Sci Rep. 2020 Mar 2;10(1):3850. doi: 10.1038/s41598-020-60615-0.
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Cardiovascular Risk Reduction with Icosapent Ethyl for Hypertriglyceridemia.依泽替米贝降低严重高甘油三酯血症患者心血管风险
N Engl J Med. 2019 Jan 3;380(1):11-22. doi: 10.1056/NEJMoa1812792. Epub 2018 Nov 10.