一种分析人尿中S-苄基-N-乙酰半胱氨酸和S-（邻甲基苄基）-N-乙酰半胱氨酸的方法。
A procedure for the analysis of S-benzyl-N-acetylcysteine and S-(o-methylbenzyl)-N-acetylcysteine in human urine.
作者信息
Norström A, Andersson B, Levin J O
出版信息
Xenobiotica. 1986 Jun;16(6):525-9. doi: 10.3109/00498258609043541.
Analytical methods for mercapturic acids, the end-products of glutathione metabolism of the industrial solvents toluene and o-xylene (i.e., S-benzyl-N-acetylcysteine and S-(o-methylbenzyl)-N-acetylcysteine), added to human urine have been developed. The sensitivity is 2 ng/microliter (R.S.D. = +/- 13%) and 1 ng/microliter (R.S.D. = +/- 6.4%) urine for S-benzyl-N-acetylcysteine and S-(o-methylbenzyl-N-acetylcysteine, respectively, when using the h.p.l.c. method. The corresponding sensitivities for the g.l.c.-mass spectrometric method are 0.5 and 0.3 ng/microliter urine, respectively.
已开发出用于分析巯基尿酸的方法，巯基尿酸是工业溶剂甲苯和邻二甲苯谷胱甘肽代谢的终产物（即S-苄基-N-乙酰半胱氨酸和S-（邻甲基苄基）-N-乙酰半胱氨酸），添加到人体尿液中。使用高效液相色谱法时，S-苄基-N-乙酰半胱氨酸和S-（邻甲基苄基）-N-乙酰半胱氨酸在尿液中的灵敏度分别为2纳克/微升（相对标准偏差=±13%）和1纳克/微升（相对标准偏差=±6.4%）。气相色谱-质谱法的相应灵敏度分别为0.5和0.3纳克/微升尿液。
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