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miRNAs 在子宫内膜癌的发生、增殖和进展中的作用。

The Role of miRNAs in the Development, Proliferation, and Progression of Endometrial Cancer.

机构信息

Department of Gynecology, Gynecology Oncology and Obstetrics, Fryderyk Chopin University Hospital, F.Szopena 2, 35-055 Rzeszow, Poland.

Laboratory of Molecular Biology, Centre for Innovative Research in Medical and Natural Sciences, Medical College of Rzeszow University, Warzywna 1a, 35-959 Rzeszow, Poland.

出版信息

Int J Mol Sci. 2023 Jul 15;24(14):11489. doi: 10.3390/ijms241411489.

Abstract

Endometrial cancer is one of the most common cancers in developing and developed countries. Although the detection of this cancer is high at the early stages, there is still a lack of markers to monitor the disease, its recurrence, and metastasis. MiRNAs are in charge of the post-transcriptional regulation of genes responsible for the most important biological processes, which is why they are increasingly used as biomarkers in many types of cancer. Many studies have demonstrated the influence of miRNAs on the processes related to carcinogenesis. The characteristics of miRNA expression profiles in endometrial cancer will allow their use as diagnostic and prognostic biomarkers. This paper focuses on the discussion of selected miRNAs based on the literature and their role in the development of endometrial cancer.

摘要

子宫内膜癌是发展中国家和发达国家最常见的癌症之一。尽管这种癌症在早期的检出率很高,但仍缺乏用于监测疾病、复发和转移的标志物。miRNAs 负责负责最重要的生物学过程的基因的转录后调控,这就是为什么它们在许多类型的癌症中越来越多地被用作生物标志物。许多研究已经证明了 miRNAs 对与癌变相关的过程的影响。子宫内膜癌中 miRNA 表达谱的特征将允许它们作为诊断和预后生物标志物的使用。本文基于文献讨论了选定的 miRNAs 及其在子宫内膜癌发展中的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1250/10380838/0d5e66505451/ijms-24-11489-g001.jpg

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