Weiner R
Z Alternsforsch. 1986 Jul-Aug;41(4):219-24.
With advancing age functional and morphological changes take place within the intestinal tract. The absorption rate (constant k12), the time of appearance of the relative maximum of the D-xylose concentrations in the blood serum after oral administration (time tm), and especially the extent of the relative absorption in the small intestine until the time tm RR (tm) determined by graphic-mathematical evaluation of the blood levels kinetics of D-xylose after oral and intravenous administration, are useful parameters for differentiation between involutively and pathological changes in intestinal absorption. Absorption disorders in old age are due to morbidity and not, sui generis, to involution.
随着年龄的增长,肠道内会发生功能和形态学变化。口服给药后血清中D-木糖浓度相对最大值出现的时间(时间tm)、吸收速率(常数k12),特别是通过对口服和静脉给药后D-木糖血药浓度动力学进行图形数学评估确定的直到时间tm时小肠内的相对吸收程度RR(tm),是区分肠道吸收的退行性变化和病理性变化的有用参数。老年期的吸收障碍是由疾病引起的,而非原发性退行性变化所致。