Weiner R, Laue R, Dietze F
Z Gesamte Inn Med. 1986 Mar 1;41(5):152-8.
With growing age functional and morphological changes in the alimentary tract appear. The age dependence of the intestinal absorption was investigated with the help of the modified D-xylose absorption test. By means of a graphic-mathematical evaluation of the blood level kinetics of D-xylose after oral and intravenous application the absorption rapidity (constant k12), the temporary position of the relative maximum of the D-xylose concentrations in the blood serum after oral application (time tm) and the size of the relative absorption of the small intestine were established depending on the time RR (t). Within the age range of 3 to 96 years it has been proven that a slowing down of the enteral absorption occurred with growing age. By prolonging the period during which the food components are absorbed in the small intestine (shift of tm towards later times) the old organism is just as capable of complete absorption as is the young one, even though the absorption processes take place at a slower rate. Absorption disorders in old age are due to morbidity and not, sui generis, to involution.
随着年龄的增长,消化道会出现功能和形态上的变化。借助改良的D-木糖吸收试验研究了肠道吸收的年龄依赖性。通过对口服和静脉注射后D-木糖血药浓度动力学进行图形-数学评估,确定了吸收速度(常数k12)、口服后血清中D-木糖浓度相对最大值的暂时位置(时间tm)以及小肠相对吸收量的大小与时间RR(t)的关系。在3至96岁的年龄范围内,已证实随着年龄的增长,肠内吸收会减慢。通过延长食物成分在小肠内的吸收时间(tm向更晚的时间偏移),老年机体与年轻机体一样能够完全吸收,尽管吸收过程发生的速率较慢。老年期的吸收障碍是由疾病引起的,而不是特殊地由退化引起的。