紫杉醇递送至脑内治疗脑胶质母细胞瘤。
Paclitaxel Delivery to the Brain for Glioblastoma Treatment.
机构信息
Institute of Drug Research, School of Pharmacy-Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel.
The Institute of Biomedical and Oral Research, Faculty of Dental Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel.
出版信息
Int J Mol Sci. 2023 Jul 21;24(14):11722. doi: 10.3390/ijms241411722.
The development of paclitaxel-loaded polymeric nanoparticles for the treatment of brain tumors was investigated. Poly(lactide-glycolide) (PLGA) nanoparticles containing 10% / paclitaxel with a particle size of 216 nm were administered through intranasal and intravenous routes to male Sprague-Dawley rats at a dose of 5 mg/kg. Both routes of administration showed appreciable accumulation of paclitaxel in brain tissue, liver, and kidney without any sign of toxicity. The anti-proliferative effect of the nanoparticles on glioblastoma tumor cells was comparable to that of free paclitaxel.
研究了载紫杉醇聚合物纳米粒用于治疗脑肿瘤。通过鼻腔内和静脉途径给予含 10%紫杉醇、粒径为 216nm 的聚（丙交酯-乙交酯）（PLGA）纳米粒，剂量为 5mg/kg 给雄性 Sprague-Dawley 大鼠。两种给药途径均显示紫杉醇在脑组织、肝脏和肾脏中有明显的蓄积，没有任何毒性迹象。纳米粒对神经胶质瘤肿瘤细胞的抗增殖作用与游离紫杉醇相当。
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