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经食管超声心动图指导预防和处理腹部常温区域灌注的陷阱并优化循环死亡后供体器官获取时的时机

Transesophageal Echocardiography Guidance to Prevent and Manage Pitfalls from Abdominal Normothermic Regional Perfusion and Optimize Timing during Organ Retrieval from a Donor after Circulatory Death.

作者信息

Bianchini Amedeo, Laici Cristiana, Miglionico Noemi, Bianchi Maria Giacinta, Tarozzi Elena, Bernardi Enrico, Toni Jessica, Cordella Erika, Vitale Giovanni, Siniscalchi Antonio

机构信息

Post-Surgical and Transplant Intensive Care Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy.

Department of Medical and Surgical Sciences (DIMEC), University of Bologna, 40126 Bologna, Italy.

出版信息

J Pers Med. 2023 Jul 24;13(7):1177. doi: 10.3390/jpm13071177.

DOI:10.3390/jpm13071177
PMID:37511790
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10381753/
Abstract

An essential means of collecting more abdominal donor organs is controlled donation after circulatory death (cDCD). The organs are typically preserved during cDCD using the abdominal normothermic regional perfusion (A-NRP) technique to recirculate oxygenated blood flow following cardiac arrest and the withdrawal of life support. One of the challenges of A-NRP is ensuring the correct vascular devices' positionings, specifically extracorporeal membrane oxygenation cannulae and aortic balloons, typically achieved through fluoroscopy with or without contrast agents. Here, we present a case report in which transesophageal echocardiography (TEE) helped the transplant team to effectively procure viable abdominal organs from a cDCD donor in the shortest time frame, as minimizing time is one of the most crucial factors in maintaining organ viability. TEE use leads to a more effective and efficient A-NRP procedure with limited complications. In addition, it allows us to observe the circulation of both the thoracic and part of the abdominal organs using one fast exam. This case is the first report describing TEE as a primary guide and useful tool for DCD donors. However, prospective studies are needed to confirm that TEE could be used as standard practice during all DCD organ retrieval procedures.

摘要

获取更多腹部供体器官的一种重要方法是心脏死亡后器官捐献(cDCD)。在cDCD过程中,通常使用腹部常温局部灌注(A-NRP)技术来保存器官,即在心脏骤停和撤除生命支持后重新循环含氧血流。A-NRP的挑战之一是确保正确放置血管装置,特别是体外膜肺氧合插管和主动脉球囊,通常通过使用或不使用造影剂的荧光透视来实现。在此,我们报告一例病例,经食管超声心动图(TEE)帮助移植团队在最短时间内有效地从一名cDCD供体获取了存活的腹部器官,因为尽量缩短时间是维持器官存活的最关键因素之一。使用TEE可使A-NRP程序更有效、更高效,且并发症有限。此外,通过一次快速检查,它能让我们观察胸部和部分腹部器官的循环情况。该病例是首例将TEE描述为DCD供体的主要引导和有用工具的报告。然而,需要进行前瞻性研究以证实TEE可在所有DCD器官获取程序中作为标准操作使用。

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本文引用的文献

1
Transesophageal Echocardiography-Guided Extracorporeal Membrane Oxygenation Cannulation in COVID-19 Patients.经食管超声心动图引导下 COVID-19 患者体外膜肺氧合置管。
J Cardiothorac Vasc Anesth. 2022 Dec;36(12):4296-4304. doi: 10.1053/j.jvca.2022.07.020. Epub 2022 Jul 30.
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EISOR Delivery: Regional experience with sharing equipe, equipment & expertise to increase cDCD donor pool in time of pandemic.EISOR 分娩:在大流行期间,通过分享团队、设备和专业知识来增加 cDCD 供体库的区域经验。
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3
Response to American College of Physician's statement on the ethics of transplant after normothermic regional perfusion.
对美国医师学院关于常温区域性灌注后移植伦理的声明的回应。
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4
Establishing a heart transplant programme using donation after circulatory-determined death donors: a United Kingdom based single-centre experience.利用循环判定死亡后捐赠者建立心脏移植项目:基于英国的单中心经验
Interact Cardiovasc Thorac Surg. 2019 Sep 1;29(3):422-429. doi: 10.1093/icvts/ivz121.
5
Kidney Transplant From Uncontrolled Donation After Circulatory Death: Contribution of Normothermic Regional Perfusion.《无控制性循环死亡后供肾移植:常温区域性灌注的贡献》。
Transplantation. 2020 Jan;104(1):130-136. doi: 10.1097/TP.0000000000002753.
6
In situ normothermic perfusion of livers in controlled circulatory death donation may prevent ischemic cholangiopathy and improve graft survival.在控制性循环死亡供肝中进行原位常温灌流可能预防缺血性胆管病并提高移植物存活率。
Am J Transplant. 2019 Jun;19(6):1745-1758. doi: 10.1111/ajt.15241. Epub 2019 Feb 1.
7
Transesophageal ultrasonography during orthotopic liver transplantation: Show me more.原位肝移植术中的经食管超声心动图:给我更多展示。
Echocardiography. 2018 Aug;35(8):1204-1215. doi: 10.1111/echo.14037. Epub 2018 Jun 2.
8
A Comprehensive Review of Transesophageal Echocardiography During Orthotopic Liver Transplantation.原位肝移植术中经食管超声心动图的综合综述
J Cardiothorac Vasc Anesth. 2018 Aug;32(4):1815-1824. doi: 10.1053/j.jvca.2018.02.033. Epub 2018 Feb 22.
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Transesophageal lung ultrasound: to boldly go….经食管肺部超声:勇敢前行……
Can J Anaesth. 2016 Nov;63(11):1211-4. doi: 10.1007/s12630-016-0703-1. Epub 2016 Jul 29.
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Transesophageal lung ultrasonography: a novel technique for investigating hypoxemia.经食管肺部超声检查:一种用于研究低氧血症的新技术。
Can J Anaesth. 2016 Nov;63(11):1266-76. doi: 10.1007/s12630-016-0702-2. Epub 2016 Jul 29.