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经食管超声心动图指导预防和处理腹部常温区域灌注的陷阱并优化循环死亡后供体器官获取时的时机

Transesophageal Echocardiography Guidance to Prevent and Manage Pitfalls from Abdominal Normothermic Regional Perfusion and Optimize Timing during Organ Retrieval from a Donor after Circulatory Death.

作者信息

Bianchini Amedeo, Laici Cristiana, Miglionico Noemi, Bianchi Maria Giacinta, Tarozzi Elena, Bernardi Enrico, Toni Jessica, Cordella Erika, Vitale Giovanni, Siniscalchi Antonio

机构信息

Post-Surgical and Transplant Intensive Care Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy.

Department of Medical and Surgical Sciences (DIMEC), University of Bologna, 40126 Bologna, Italy.

出版信息

J Pers Med. 2023 Jul 24;13(7):1177. doi: 10.3390/jpm13071177.

Abstract

An essential means of collecting more abdominal donor organs is controlled donation after circulatory death (cDCD). The organs are typically preserved during cDCD using the abdominal normothermic regional perfusion (A-NRP) technique to recirculate oxygenated blood flow following cardiac arrest and the withdrawal of life support. One of the challenges of A-NRP is ensuring the correct vascular devices' positionings, specifically extracorporeal membrane oxygenation cannulae and aortic balloons, typically achieved through fluoroscopy with or without contrast agents. Here, we present a case report in which transesophageal echocardiography (TEE) helped the transplant team to effectively procure viable abdominal organs from a cDCD donor in the shortest time frame, as minimizing time is one of the most crucial factors in maintaining organ viability. TEE use leads to a more effective and efficient A-NRP procedure with limited complications. In addition, it allows us to observe the circulation of both the thoracic and part of the abdominal organs using one fast exam. This case is the first report describing TEE as a primary guide and useful tool for DCD donors. However, prospective studies are needed to confirm that TEE could be used as standard practice during all DCD organ retrieval procedures.

摘要

获取更多腹部供体器官的一种重要方法是心脏死亡后器官捐献(cDCD)。在cDCD过程中,通常使用腹部常温局部灌注(A-NRP)技术来保存器官,即在心脏骤停和撤除生命支持后重新循环含氧血流。A-NRP的挑战之一是确保正确放置血管装置,特别是体外膜肺氧合插管和主动脉球囊,通常通过使用或不使用造影剂的荧光透视来实现。在此,我们报告一例病例,经食管超声心动图(TEE)帮助移植团队在最短时间内有效地从一名cDCD供体获取了存活的腹部器官,因为尽量缩短时间是维持器官存活的最关键因素之一。使用TEE可使A-NRP程序更有效、更高效,且并发症有限。此外,通过一次快速检查,它能让我们观察胸部和部分腹部器官的循环情况。该病例是首例将TEE描述为DCD供体的主要引导和有用工具的报告。然而,需要进行前瞻性研究以证实TEE可在所有DCD器官获取程序中作为标准操作使用。

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