Chukyo Eye Clinic, Nagoya 456-0032, Aichi, Japan.
General Aoyama Hospital, Toyokawa 441-0103, Aichi, Japan.
Medicina (Kaunas). 2023 Jul 10;59(7):1282. doi: 10.3390/medicina59071282.
: In this study, we aimed to compare the physical properties of hole-implantable collamer lenses (H-ICLs) and implantable phakic contact lenses (IPCLs) and investigate their flexural and cell adhesion characteristics. : Transverse compression load to achieve lens flexion and static Young's modulus were measured in H-ICLs and IPCLs using designated equipment. Load was measured both with and without restraining the optic section of the lenses. Adhesion of iHLEC-NY2 cells to the lens surfaces was examined using phase-contrast microscopy, and cell proliferation activity was evaluated using WST-8 assay. : The H-ICL showed a greater tendency for transverse compression load compared to IPCL, while the IPCL showed a higher Young's modulus with respect to the force exerted on the center of the anterior surface of the optic section. The joint between the optic section and haptic support in the IPCL was found to mitigate the effects of transverse compression load. Both lens types showed minimal cell adhesion. : Our findings indicate that H-ICLs and IPCLs exhibit distinct physical properties and adhesive characteristics. The IPCL demonstrated higher Young's modulus and unique structural features, while the H-ICL required greater transverse compression load to achieve the flexion required to tuck the haptic supports into place behind the iris to fix the lens. The observed cell non-adhesive properties for both lens types are promising in terms of reducing complications related to cell adhesion. However, further investigation and long-term observation of IPCL are warranted to assess its stability and potential impact on the iris. These findings contribute to a better understanding of the performance and potential applications of H-ICLs and IPCLs in ophthalmology.
: 在这项研究中，我们旨在比较孔植入式 Collamer 透镜（H-ICL）和有晶状体眼接触镜（ICL）的物理特性，并研究它们的挠曲和细胞黏附特性。: 使用专用设备测量 H-ICL 和 IPCL 中镜片弯曲的横向压缩负载和静态杨氏模量。在有和没有约束镜片光学部分的情况下测量负载。使用相差显微镜检查 iHLEC-NY2 细胞在镜片表面的黏附情况，并使用 WST-8 测定法评估细胞增殖活性。: H-ICL 显示出比 IPCL 更大的横向压缩负载倾向，而 IPCL 显示出与施加在前表面光学部分中心的力相比具有更高的杨氏模量。在 IPCL 中，光学部分和触觉支撑之间的连接处被发现减轻了横向压缩负载的影响。两种镜片类型的细胞黏附均较少。: 我们的研究结果表明，H-ICL 和 IPCL 表现出不同的物理特性和黏附特性。IPCL 表现出更高的杨氏模量和独特的结构特征，而 H-ICL 则需要更大的横向压缩负载才能实现将触觉支撑折叠到虹膜后面以固定镜片所需的弯曲。两种镜片类型观察到的细胞非黏附特性在减少与细胞黏附相关的并发症方面具有很大的潜力。然而，需要对 IPCL 进行进一步的研究和长期观察，以评估其稳定性和对虹膜的潜在影响。这些发现有助于更好地了解 H-ICL 和 IPCL 在眼科学中的性能和潜在应用。
