Gastroenterology Department, Ankara Ataturk Sanatoriıum Training and Research Hospital, 06290 Ankara, Turkey.
Medicina (Kaunas). 2023 Jul 12;59(7):1287. doi: 10.3390/medicina59071287.
The neutrophil-lymphocyte ratio (NLR) can be helpful both in demonstrating acute and chronic liver injury and predicting malignant potential. The mean platelet volume (MPV) is also a marker that can be used as a risk indicator in atherosclerosis-associated diseases, reflecting inflammation. Within the scope of this research, we aimed to elucidate the relationship between the mean platelet volume and neutrophil-lymphocyte ratio in liver fibrosis in chronic hepatitis B patients. A total of 84 patients who were followed up with the diagnosis of chronic hepatitis B and who underwent liver biopsy were included in this prospective study. Complete blood count parameters (neutrophil, lymphocyte, neutrophil-lymphocyte ratio, hemoglobin, thrombocyte, MCV, and MPV values), demographic data, biochemistry panel (AST, ALT), HBV DNA, and liver biopsy fibrosis scores obtained from hospital database were analyzed. Since the follow-up period of chronic hepatitis B patients is six months, patients were screened in order to include a full 3-year screening pool. A total of 84 patients were enrolled within the scope of this study. The chronicity index was '0' in 7.1% ( = 6), '1' in 23.8% ( = 20), '2' in 56% ( = 47), and '3' in 13.1% ( = 11)of the patients. According to the chronicity index groups, there was a statistically significant difference between the medians of the hepatitis activity index (HAI) values at the 5% significance level ( < 0.001). The correlation analysis revealed a statistically significant relationship between the chronicity index and the mean platelet volume to lymphocyte ratio (MPVL). However, considering the degree of the relationship, it can be said that it was a positive and weak relationship ( = 0.046, r = 0.218). Regarding the outcomes of this research, a significant relationship was found between the neutrophil-lymphocyte ratio, mean platelet volume, and fibrosis.
中性粒细胞与淋巴细胞比值（NLR）在显示急性和慢性肝损伤以及预测恶性潜能方面均有帮助。平均血小板体积（MPV）也是一种标志物，可作为动脉粥样硬化相关疾病的风险指标，反映炎症。在本研究范围内，我们旨在阐明慢性乙型肝炎患者肝纤维化中平均血小板体积与中性粒细胞与淋巴细胞比值之间的关系。
本前瞻性研究共纳入 84 例经诊断为慢性乙型肝炎并接受肝活检的患者。从医院数据库中分析了全血细胞计数参数（中性粒细胞、淋巴细胞、中性粒细胞与淋巴细胞比值、血红蛋白、血小板、MCV 和 MPV 值）、人口统计学数据、生物化学指标（AST、ALT）、HBV DNA 和肝活检纤维化评分。由于慢性乙型肝炎患者的随访期为 6 个月，因此对患者进行了筛查，以纳入完整的 3 年筛查队列。本研究共纳入 84 例患者。患者的慢性指数分别为 0（ = 6）、1（ = 20）、2（ = 47）和 3（ = 11），占 7.1%、23.8%、56%和 13.1%。根据慢性指数组，在 5%的显著水平（ < 0.001）下，肝炎活动指数（HAI）值的中位数存在统计学差异。相关性分析显示，慢性指数与平均血小板体积与淋巴细胞比值（MPVL）之间存在统计学显著关系。然而，考虑到关系的程度，可以说这是一种阳性且较弱的关系（ = 0.046，r = 0.218）。
关于本研究的结果，发现中性粒细胞与淋巴细胞比值、平均血小板体积与纤维化之间存在显著关系。
