Division of Cardiology, Department of Internal Medicine, Dongguk University Gyeongju Hospital, Dongguk University College of Medicine, Gyeongju 38067, Republic of Korea.
Department of Neurology, Dongguk University Gyeongju Hospital, Dongguk University College of Medicine, Gyeongju 38067, Republic of Korea.
Medicina (Kaunas). 2023 Jul 14;59(7):1300. doi: 10.3390/medicina59071300.
: Essential thrombocythemia (ET) is a chronic myeloproliferative neoplasm characterized by elevated platelet counts and an increased risk of thrombotic events, including ischemic strokes. Materials and : We conducted a retrospective analysis of data from consecutive ischemic stroke patients with ET between March 2014 and February 2023. : This case series describes the clinical presentation, radiological features, and management of five patients with ET-associated ischemic strokes, all harboring the mutation. The diverse radiological findings suggest that both large and small vessel diseases may be influenced by the prothrombotic state induced by ET. A significant elevation in platelet count was observed to correlate with the emergence of new acute infarctions in some cases. : The study highlights combined use of antiplatelet and cytoreductive therapy in preventing secondary stroke events in patients with ET and mutations. The heterogeneity of stroke patterns in this population necessitates a comprehensive understanding of the underlying pathophysiological mechanisms and tailored therapeutic approaches.
原发性血小板增多症（ET）是一种以血小板计数升高和血栓事件风险增加为特征的慢性骨髓增殖性肿瘤，包括缺血性中风。
我们对 2014 年 3 月至 2023 年 2 月期间连续发生 ET 相关缺血性中风的患者进行了回顾性数据分析。
本病例系列描述了 5 例 ET 相关缺血性中风患者的临床表现、影像学特征和治疗方法，这些患者均携带 JAK2 V617F 突变。不同的影像学表现提示，ET 引起的促血栓状态可能同时影响大血管和小血管疾病。在某些情况下，血小板计数的显著升高与新的急性梗死的出现相关。
该研究强调了在 ET 和 JAK2 V617F 突变患者中联合使用抗血小板和细胞减少治疗以预防继发性中风事件的重要性。该人群中风模式的异质性需要全面了解潜在的病理生理机制和个体化治疗方法。
