Valtetsiotis Konstantinos, Di Martino Alberto, Brunello Matteo, Tassinari Leonardo, D'Agostino Claudio, Traina Francesco, Faldini Cesare
Department of Biomedical and Neuromotor Science-DIBINEM, University of Bologna, 40127 Bologna, Italy.
1st Orthopedic and Traumatology Department, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, Italy.
Microorganisms. 2023 Jul 9;11(7):1778. doi: 10.3390/microorganisms11071778.
(1) Background: Periprosthetic joint infections (PJIs) represent a small yet important risk when undertaking a joint arthroplasty; they occur in approximately 1-2% of treatments. These infections create a medical and financial burden for patients and healthcare systems. Despite the introduction of recognized best clinical practices during arthroplasty operations, it is not yet possible to further reduce the risk of infection after surgery. The purpose of this review is to raise awareness of the potential role of gut dysbiosis in the development of PJIs and to highlight the potential of the gut bacteriome as a possible target for preventing them. (2) Methods: We compiled all the available data from five databases, examining the effects of gut dysbiosis in human and murine studies, following PRISMA guidelines, for a total of five reviewed studies. (3) Results: One human and one murine study found the Trojan horse theory applicable. Additionally, inflammatory bowel diseases, gut permeability, and oral antibiotic ingestion all appeared to play a role in promoting gut dysbiosis to cause PJIs, according to the other three studies. (4) Conclusions: Gut dysbiosis is linked to an increased risk of PJI.
(1) 背景：人工关节周围感染（PJI）是关节置换手术中虽小但重要的风险；约1-2%的治疗会发生此类感染。这些感染给患者和医疗系统带来了医疗和经济负担。尽管在关节置换手术中引入了公认的最佳临床实践，但术后仍无法进一步降低感染风险。本综述的目的是提高人们对肠道菌群失调在PJI发生发展中潜在作用的认识，并强调肠道菌群作为预防PJI可能靶点的潜力。(2) 方法：我们按照PRISMA指南，汇总了五个数据库中的所有可用数据，研究了肠道菌群失调在人类和小鼠研究中的影响，共五项综述研究。(3) 结果：一项人类研究和一项小鼠研究发现“特洛伊木马”理论适用。另外三项研究表明，炎症性肠病、肠道通透性和口服抗生素摄入似乎都在促进肠道菌群失调导致PJI方面发挥了作用。(4) 结论：肠道菌群失调与PJI风险增加有关。
