Riga T N, Getsova V M, Mikhaĭlova N G, Zaĭchenko M I, Kuliev E I
Zh Vyssh Nerv Deiat Im I P Pavlova. 1986 May-Jun;36(3):482-9.
In experiments on rats, the influence was studied of dalargin on the elaboration and preservation of various homogeneous and heterogeneous conditioned reflexes (CRs) elaborated in single and multiple pairings. The effect of dalargin on the processes of learning and memory was compared with the action of the peptide on the activity of hypothalamic neurones. Administration of dalargin delayed the elaboration of maze defensive CRs and practically did not affect the elaboration of two-way avoidance. The preservation of CR also deteriorated under the influence of dalargin. Administration of dalargin 10 min before the CRs testing did not prevent their reproduction. When using CRs elaborated in a single pairing, dalargin disturbed the preservation of the drinking CR and improved that of passive avoidance CR. Dalargin in this dose affected the emotional state of animals in the open field and did not significantly affect their motor activity. Dalargin suppressed impulse activity in 17 out of 22 tested neurones of the lateral hypothalamus, with maximum effect in 20-50 min after its administration. The obtained data show that the character of dalargin action on the elaboration of CR and mainly on its consolidation, depends on the character of the elaborated CR and is probably due to great extent to the effect of the peptide on the brain emotional mechanisms.
在对大鼠的实验中，研究了达乐argin对单次和多次配对中形成和保留的各种均匀和异质条件反射（CRs）的影响。将达乐argin对学习和记忆过程的作用与该肽对下丘脑神经元活动的作用进行了比较。给予达乐argin延迟了迷宫防御性CRs的形成，并且实际上并未影响双向回避的形成。在达乐argin的影响下，CRs的保留也变差了。在CRs测试前10分钟给予达乐argin并不能阻止它们的再现。当使用单次配对中形成的CRs时，达乐argin干扰了饮水CRs的保留并改善了被动回避CRs的保留。该剂量的达乐argin影响动物在旷场中的情绪状态，并且对其运动活动没有显著影响。达乐argin抑制了22个测试的下丘脑外侧神经元中的17个的冲动活动，给药后20 - 50分钟效果最大。获得的数据表明，达乐argin对CRs形成的作用特点，主要是对其巩固的作用特点，取决于所形成的CRs的特点，并且在很大程度上可能是由于该肽对大脑情绪机制的影响。
