Tolpyshev B A
Zh Vyssh Nerv Deiat Im I P Pavlova. 1986 May-Jun;36(3):545-53.
In experiments on cats it is established that between the degree of EEG desynchronization in the sensorimotor cortex and expressiveness of the stereotype movements, a dissociation is possible which is most distinctly revealed in comparative studies of haloperidol, clozapine and metoclopramide--neuroleptics with different correlation of antipsychotic and extra-pyramidal properties. Local destruction of the ventral parts of the caudate nucleus head enhances motor disturbances resulting from amphetamine administration, but weakens its effect on the cortex. Elimination of the dorsal parts produces an opposite effect. It is suggested that the cause of the dissociation consists in different sensitivity to amphetamine of the dorsal and ventral parts of the neostriatum which are differently involved in organization of stereotype movements and EEG disturbances in amphetamine stereotypy.
在对猫的实验中发现，感觉运动皮层脑电图去同步化程度与刻板运动的表现力之间可能存在分离，这在对氟哌啶醇、氯氮平和甲氧氯普胺（具有不同抗精神病和锥体外系特性相关性的抗精神病药物）的比较研究中最为明显地体现出来。尾状核头部腹侧部分的局部破坏会增强安非他命给药引起的运动障碍，但会减弱其对皮层的作用。消除背侧部分则产生相反的效果。有人认为，这种分离的原因在于新纹状体背侧和腹侧部分对安非他命的敏感性不同，它们在安非他命刻板症中刻板运动和脑电图紊乱的组织过程中参与程度不同。
