Arushanian E B, Tolpyshev B A
Biull Eksp Biol Med. 1978 May;85(5):541-4.
In unrestrained cats clozapine in increasing doses (1--5 mg/kg) caused a behavioural depression and suppression of amphetamine-induced stereotypy of behaviour against the background of marked vegetative shifts. Similarly to chlorpromazine clozapine intensified the behavioural arrest reaction) and electrographic (neocortical caudate spindle) indices of the arrest function of the caudate nucleus. Arrest reaction changed more distinctly in stimulation of the ventral parts of the head of the nucleus. Clozapine also eliminated the weakening of the caudate responses caused by the stereotypical doses of amphetamine.
在未加约束的猫身上，剂量递增的氯氮平（1 - 5毫克/千克）在出现明显植物性变化的背景下，会导致行为抑制以及对苯丙胺诱导的刻板行为的抑制。与氯丙嗪类似，氯氮平增强了行为停滞反应以及尾状核停滞功能的脑电图（新皮质 - 尾状核纺锤波）指标。在刺激尾状核头部腹侧部分时，停滞反应变化更为明显。氯氮平还消除了由苯丙胺刻板剂量引起的尾状核反应减弱。
