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[氟哌啶醇和氯氮平对猫苯丙胺刻板行为节律特征的影响特点]

[Characteristics of the effect of haloperidol and clozapine on the rhythmic features of phenamine sterotypy in cats].

作者信息

Tolpyshev B A, Arushanian E B

出版信息

Farmakol Toksikol. 1984 Nov-Dec;47(6):20-5.

PMID:6542875
Abstract

Experiments on cats with the use of an electromechanical rotameter enabling one to separately record head turns to the right and to the left were made to examine the action of the neuroleptics on the time-course of changes in the horizontal component of amphetamine stereotypy. It was shown that haloperidol which destabilizes the oscillatory curve of the rate of head turns led to a progressive decrease in the number of movements. Clazapine also destabilized the rhythmic process. However, increasing the amplitude of oscillations the drug made the curve phasic in nature. Both the neuroleptics caused synchronization of the oscillation rate of head turns to the right and to the left.

摘要

利用一种机电式转子流量计对猫进行实验,该流量计能够分别记录头部向右和向左的转动,以研究抗精神病药物对苯丙胺刻板行为水平分量变化时间进程的作用。结果表明,使头部转动速率的振荡曲线不稳定的氟哌啶醇导致运动次数逐渐减少。氯氮平也使节律性过程不稳定。然而,该药物增加振荡幅度后使曲线具有相位性。这两种抗精神病药物都导致头部向右和向左转动的振荡速率同步。

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