Barczak Mariusz, Pietras-Ożga Dorota, Seliem Moaaz K, de Falco Giacomo, Giannakoudakis Dimitrios A, Triantafyllidis Konstantinos
Institute of Chemical Sciences, Faculty of Chemistry, Maria Curie-Sklodowska University, Maria Curie-Sklodowska Sq. 3, 20-031 Lublin, Poland.
Department of Epizootiology and Clinic of Infectious Diseases, Faculty of Veterinary Medicine, University of Life Sciences of Lublin, 20-612 Lublin, Poland.
Nanomaterials (Basel). 2023 Jul 13;13(14):2065. doi: 10.3390/nano13142065.
Mesoporous silicas synthesized by the co-condensation of two and three different silica monomers were synthesized by varying the time intervals between the addition of individual monomers, while the total time interval was kept constant. This resulted in different structural properties of the final silicas, particularly in their porosity and local ordering. One of the obtained samples exhibited an unusual isotherm with two hysteresis loops and its total pore volume was as high as 2.2 cm/g. In addition, to be thoroughly characterized by a wide range of instrumental techniques, the obtained materials were also employed as the adsorbents and release platforms of a diclofenac sodium (DICL; used here as a model drug). In the case of DICL adsorption and release, differences between the samples were also revealed, which confirms the fact that time control of a monomer addition can be successfully used to fine-tune the properties of organo-silica materials.
通过改变单个单体添加之间的时间间隔，同时保持总时间间隔恒定，合成了由两种和三种不同二氧化硅单体共缩合而成的介孔二氧化硅。这导致了最终二氧化硅不同的结构性质，特别是它们的孔隙率和局部有序性。所获得的样品之一表现出具有两个滞后环的异常等温线，其总孔体积高达2.2 cm/g。此外，为了通过广泛的仪器技术进行全面表征，所获得的材料还被用作双氯芬酸钠（DICL；这里用作模型药物）的吸附剂和释放平台。在DICL吸附和释放的情况下，样品之间的差异也被揭示出来，这证实了单体添加的时间控制可以成功用于微调有机硅材料性质这一事实。
