Ni(II)-Salophen 的电化学和光谱特性及生物学研究综合分析。

Ni(II)-Salophen-Comprehensive Analysis on Electrochemical and Spectral Characterization and Biological Studies.

机构信息

Coordination Chemistry Laboratory, Department of Inorganic Chemistry, Faculty of Science, University of Yaounde 1, Yaounde P.O. Box 812, Cameroon.

Faculty of Chemical Engineering and Biotechnologies, University "Politehnica" of Bucharest, Gheorghe Polizu 1-7, Sector 1, 011061 Bucharest, Romania.

出版信息

Molecules. 2023 Jul 17;28(14):5464. doi: 10.3390/molecules28145464.

New aspects of the Ni(II)-salophen complex and salophen ligand precursor were found during deep electrochemical and optical characterization, as well as biological studies for new pharmacological applications. Physicochemical and spectroscopic methods (H- and C-NMR, FT-IR and UV-Vis, electrospray ionization mass spectroscopy, thermogravimetric analysis, and molar conductance measurements) were also used to prove that the salophen ligand acts as a tetradentate and coordinates to the central metal through nitrogen and oxygen atoms. The electrochemical behavior of the free Schiff salophen ligand (H) and its Ni(II) complex (Ni(II)) was deeply studied in tetrabutylammonium perchlorate solutions in acetonitrile via CV, DPV, and RDE. Blue films on the surfaces of the electrodes as a result of the electropolymerization processes were put in evidence and characterized via CV and DPV. (H) and Ni(II) complexes were tested for their antimicrobial, antifungal, and antioxidant activity, showing good antimicrobial and antifungal activity against several bacteria and fungi.

在深入的电化学和光学表征以及新的药理学应用的生物研究中，发现了 Ni(II)-salophen 配合物和 salophen 配体前体的新方面。还使用了物理化学和光谱方法（H 和 C-NMR、FT-IR 和 UV-Vis、电喷雾电离质谱、热重分析和摩尔电导率测量）来证明 salophen 配体作为四齿配体通过氮和氧原子与中心金属配位。通过循环伏安法、差分脉冲伏安法和旋转圆盘电极法在四丁基高氯酸铵在乙腈中的溶液中深入研究了游离席夫碱 salophen 配体（H）及其 Ni(II)配合物（Ni(II)）的电化学行为。通过 CV 和 DPV 证明了由于电聚合过程在电极表面上形成的蓝色薄膜，并对其进行了表征。（H）和 Ni(II)配合物进行了抗菌、抗真菌和抗氧化活性测试，对几种细菌和真菌表现出良好的抗菌和抗真菌活性。