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三萜酸复合物（TAC）和硒代蛋氨酸（MSC）的合理组合通过 PI3K/Akt/GSK3β 通路改善葡萄糖和脂质代谢。

A Rational Combination of Triterpene Acid Complex (TAC) and Se-Methylselenocysteine (MSC) Improves Glucose and Lipid Metabolism via the PI3K/Akt/GSK3β Pathway.

机构信息

College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.

Wuhan Bestcarrier Biotechnology Co., Ltd., Wuhan 430075, China.

出版信息

Molecules. 2023 Jul 19;28(14):5499. doi: 10.3390/molecules28145499.

DOI:10.3390/molecules28145499
PMID:37513373
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10385649/
Abstract

(CP) contains triterpene acids that can improve glucose and lipid metabolism disorders. However, controlling the composition and content of these active ingredients in CP extracts is challenging. The main active components in CP triterpene acids, including ursolic acid (UA), oleanolic acid (OA), and betulinic acid (BA), exhibit antihyperglycemic and antihypertensive effects. The response surface methodology was utilized to design and optimize the ratio of UA, OA, and BA based on the inhibition rate of pancrelipase and α-amylase. The proportional mixture of UA, OA, and BA resulted in the formation of a complex known as triterpenoid acid (TAC). Se-methylselenocysteine (MSC), a compound with various physiological functions such as antioxidant properties and tumor inhibition, has been used in combination with TAC to form the TAC/MSC complex. Our data demonstrate that TAC/MSC improved palmitic acid (PA)-induced insulin resistance in HepG2 cells through activating the phosphoinositide 3-kinase (PI3K) /protein kinase B (AKT)/glycogen synthase kinase 3 beta (GSK3β) pathway. Moreover, TAC/MSC effectively improved hyperglycemia, glucose intolerance, insulin resistance, and lipid metabolism disorder in mice with type 2 diabetes mellitus (T2DM), attenuated hepatic steatosis, and reduced oxidative stress to alleviate T2DM characteristics.

摘要

（CP）含有三萜酸，可改善葡萄糖和脂质代谢紊乱。然而，控制 CP 提取物中这些活性成分的组成和含量具有挑战性。CP 三萜酸中的主要活性成分，包括熊果酸（UA）、齐墩果酸（OA）和白桦脂酸（BA），具有降血糖和降血压的作用。本研究采用响应面法，根据对胰脂肪酶和α-淀粉酶的抑制率，设计并优化了 UA、OA 和 BA 的比例。UA、OA 和 BA 的比例混合物形成了一种称为三萜酸（TAC）的复合物。具有抗氧化和抑制肿瘤等多种生理功能的化合物 Se-甲基硒代半胱氨酸（MSC）与 TAC 联合形成 TAC/MSC 复合物。我们的数据表明，TAC/MSC 通过激活磷酸肌醇 3-激酶（PI3K）/蛋白激酶 B（AKT）/糖原合成酶激酶 3β（GSK3β）通路，改善了棕榈酸（PA）诱导的 HepG2 细胞胰岛素抵抗。此外，TAC/MSC 有效改善了 2 型糖尿病（T2DM）小鼠的高血糖、葡萄糖耐量异常、胰岛素抵抗和脂质代谢紊乱，减轻了肝脂肪变性，降低了氧化应激，缓解了 T2DM 的特征。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c2c/10385649/d83a18c86f35/molecules-28-05499-g013.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c2c/10385649/4e84a77060ab/molecules-28-05499-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c2c/10385649/16c283ac3cb6/molecules-28-05499-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c2c/10385649/1e478c10dbed/molecules-28-05499-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c2c/10385649/543968b89099/molecules-28-05499-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c2c/10385649/1aa109397bdc/molecules-28-05499-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c2c/10385649/ff9cd48bae3e/molecules-28-05499-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c2c/10385649/31dc405c28c4/molecules-28-05499-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c2c/10385649/d83a18c86f35/molecules-28-05499-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c2c/10385649/f9f0efed8292/molecules-28-05499-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c2c/10385649/ac2042aab71d/molecules-28-05499-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c2c/10385649/551d39145de1/molecules-28-05499-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c2c/10385649/809425f95764/molecules-28-05499-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c2c/10385649/9c5ac3553af9/molecules-28-05499-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c2c/10385649/4e84a77060ab/molecules-28-05499-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c2c/10385649/16c283ac3cb6/molecules-28-05499-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c2c/10385649/1e478c10dbed/molecules-28-05499-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c2c/10385649/543968b89099/molecules-28-05499-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c2c/10385649/1aa109397bdc/molecules-28-05499-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c2c/10385649/ff9cd48bae3e/molecules-28-05499-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c2c/10385649/31dc405c28c4/molecules-28-05499-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c2c/10385649/d83a18c86f35/molecules-28-05499-g013.jpg

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