来自青钱柳叶的植物化学物质及其对 11β-HSD1 酶的抑制作用。
Phytochemicals from the Leaves of Cyclocarya paliurus and their 11β-HSD1 Enzyme Inhibitory Effects.
机构信息
State Key Laboratory of Phytochemistry and Plant Resources in West China, and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, P. R. China.
Yunnan University of Chinese Medicine, Kunming, 650500, P. R. China.
出版信息
Chem Biodivers. 2021 Jan;18(1):e2000772. doi: 10.1002/cbdv.202000772. Epub 2020 Dec 28.
Two new dammarane-type triterpenoid saponins, 3β-(α-l-arabinopyranosyloxy)-24,25-dihydroxydammar-20-en-12α-yl 6-deoxy-β-d-glucopyranoside (1) and (24R)-3β-[(4-O-acetyl-α-l-arabinopyranosyl)oxy]-25-hydroxy-20,24-epoxydammaran-12β-yl 6-deoxy-β-d-glucopyranoside (2), and fourteen known triterpenoids were isolated from the 70 % MeOH extract of the leaves of Cyclocarya paliurus. Their structures were established based on analyses of spectroscopic data. All compounds were tested for their inhibitory activities against the 11β-HSD1 enzyme. Hederagenin (13) exhibited moderate inhibitory effect for mouse 11β-HSD1 with an IC value of 0.16±0.04 μM.
从青钱柳叶的 70%甲醇提取物中分离得到两种新的达玛烷型三萜皂苷，分别为 3β-(α-l-阿拉伯吡喃糖氧基)-24,25-二羟基达玛-20-烯-12α-yl 6-去氧-β-d-吡喃葡萄糖苷（1）和（24R）-3β-[(4-O-乙酰基-α-l-阿拉伯吡喃糖基)氧基]-25-羟基-20,24-环氧达玛烷-12β-yl 6-去氧-β-d-吡喃葡萄糖苷（2），以及 14 种已知的三萜类化合物。基于光谱数据分析确定了它们的结构。所有化合物均测试了对 11β-HSD1 酶的抑制活性。荭草苷（13）对小鼠 11β-HSD1 表现出中等抑制作用，IC 值为 0.16±0.04 μM。
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