Cejas-Sánchez Joel, Kajetanowicz Anna, Grela Karol, Caminade Anne-Marie, Sebastián Rosa María
Biological and Chemical Research Centre, Faculty of Chemistry, University of Warsaw, Żwirki i Wigury 101, 02-089 Warsaw, Poland.
Department of Chemistry, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Bellaterra, 08193 Barcelona, Spain.
Molecules. 2023 Jul 21;28(14):5570. doi: 10.3390/molecules28145570.
Dendrimers, being highly branched monodispersed macromolecules, predominantly exhibit identical terminal functionalities within their structural framework. Nonetheless, there are instances where the presence of two distinct surface functionalities becomes advantageous for the fulfilment of specific properties. To achieve this objective, one approach involves implementing Janus dendrimers, consisting of two dendrimeric wedges terminated by dissimilar functionalities. The prevalent method for creating these structures involves the synthesis of dendrons that possess a core functionality that complements that of a second dendron, facilitating their coupling to generate the desired dendrimers. In this comprehensive review, various techniques employed in the fabrication of phosphorus-based Janus dendrimers are elucidated, displaying the different coupling methodologies employed between the two units. The advantages of phosphorus dendrimers over classic dendrimers will be shown, as the presence of at least one phosphorus atom in each generation allows for the easy monitoring of reactions and the confirmation of purity through a simple technique such as P NMR, as these structures typically exhibit easily interpretable patterns.
树枝状大分子是高度支化的单分散大分子，在其结构框架内主要表现出相同的末端官能团。然而，在某些情况下，存在两种不同的表面官能团对于实现特定性能是有利的。为了实现这一目标，一种方法是采用Janus树枝状大分子，它由两个由不同官能团终止的树枝状楔形物组成。创建这些结构的常用方法是合成具有与第二个树枝状分子互补的核心官能团的树枝状分子，促进它们的偶联以生成所需的树枝状大分子。在这篇全面的综述中，阐述了用于制备磷基Janus树枝状大分子的各种技术，展示了两个单元之间采用的不同偶联方法。将展示磷树枝状大分子相对于经典树枝状大分子的优势，因为每一代中至少存在一个磷原子使得通过诸如P NMR这样的简单技术易于监测反应并确认纯度，因为这些结构通常表现出易于解释的图谱。
