Department of Pediatrics, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China.
Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China.
Nutrients. 2023 Jul 11;15(14):3104. doi: 10.3390/nu15143104.
We aimed to examine the effects of various severities of hypertensive disorders in pregnancy on birthweight, blood pressure (BP), and body mass index in offspring at age 7. In the China Labor and Delivery Survey and the United States Collaborative Perinatal Project (CPP), the relationship of the severity of hypertensive disorders and nutritional and cardiovascular outcomes in offspring was assessed using a multivariable logistic and general linear regression model. In both datasets, those with gestational hypertension were more likely to deliver large for gestational age (LGA) and macrosomia (adjusted odds ratios (aOR) ranged from 1.29 to 1.91), as well as low birth weight (LBW) neonates (aOR ranged from 1.23 to 3.56), compared with normotensive mothers. In the CPP, when gestational hypertension was further stratified into mild and severe, only those with mild gestational hypertension (the mild group) were more likely to deliver macrosomia and LGA (aOR ranged from 1.25 to 1.32). Others (severe gestational hypertension and preeclampsia/eclampsia) were closely related to LBW and small for gestational age (aOR ranged from 1.27 to 2.77). Moreover, children of mothers in the mild group tended to be overweight/obese and had elevated diastolic BP. We concluded that the severity of hypertensive disorders had different effects on birthweight, childhood overweight, and BP.
我们旨在研究妊娠高血压疾病的不同严重程度对 7 岁儿童出生体重、血压和体质量指数的影响。在中国劳动力和分娩调查（China Labor and Delivery Survey）和美国合作围产期项目（United States Collaborative Perinatal Project，CPP）中，使用多变量逻辑回归和广义线性回归模型评估了高血压疾病严重程度与后代营养和心血管结局的关系。在这两个数据集，妊娠期高血压的孕妇更有可能分娩大于胎龄儿（LGA）和巨大儿（校正比值比（adjusted odds ratios，aOR）范围为 1.29 至 1.91），以及低出生体重（LBW）新生儿（aOR 范围为 1.23 至 3.56），与血压正常的母亲相比。在 CPP 中，当将妊娠期高血压进一步分为轻度和重度时，只有轻度妊娠期高血压（轻度组）的孕妇更有可能分娩巨大儿和 LGA（aOR 范围为 1.25 至 1.32）。其他（重度妊娠期高血压和子痫前期/子痫）与 LBW 和小于胎龄儿（small for gestational age，SGA）密切相关（aOR 范围为 1.27 至 2.77）。此外，轻度组母亲的孩子往往超重/肥胖，舒张压升高。我们得出结论，高血压疾病的严重程度对出生体重、儿童超重和血压有不同的影响。
