REALIFE Research Group, Research Unit Woman and Child, Department of Development and Regeneration, KU Leuven, 3000 Leuven, Belgium.
Department of Obstetrics and Gynecology, University Hospital Leuven, 3000 Leuven, Belgium.
Nutrients. 2023 Jul 14;15(14):3152. doi: 10.3390/nu15143152.
Mental health problems and obesity are two common complications during pregnancy and postpartum. The preconception period is considered an appropriate period for prevention. Therefore, insights into interpregnancy mental health and the impact on weight and body composition are of interest to developing effective weight management strategies. The primary aim of this study is to assess the difference in women's mental health during the interpregnancy period and the association with pre-pregnancy body mass index (BMI) and body composition. The secondary aim is to study whether this association is affected by socio-demographic factors, interpregnancy interval and sleep. The study is a secondary analysis of the INTER-ACT e-health-supported lifestyle trial. Women were eligible if they had a subsequent pregnancy and mental health measurements at 6 weeks after childbirth and at the start of the next pregnancy ( = 276). We used univariate analyses to assess differences in mental health and performed regression analysis to assess their association with pre-pregnancy BMI and body composition at the start of the next pregnancy. Our results show a statistically significant increase in anxiety and depressive symptoms between 6 weeks after childbirth and the start of the next pregnancy (sSTAI-6 ≥ 40: +13%, =≤ 0.001; GMDS ≥ 13: +9%, = 0.01). Of the women who were not anxious at 6 weeks after childbirth (sSTAI < 40), more than one-third (39%) developed anxiety at the start of the next pregnancy ( =≤ 0.001). Regression analysis showed that sense of coherence (SOC-13) at the start of the next pregnancy was independently associated with women's pre-pregnancy BMI and fat percentage. We believe that the development of preconception lifestyle interventions that focus on both weight reduction and support in understanding, managing and giving meaning to stressful events (sense of coherence) may be of added value in optimizing women's preconception health.
心理健康问题和肥胖是妊娠和产后的两种常见并发症。孕前阶段被认为是预防的适当时期。因此，了解孕间心理健康及其对体重和身体成分的影响，对于制定有效的体重管理策略很有意义。本研究的主要目的是评估女性在孕间期间心理健康状况的差异，以及与孕前体重指数（BMI）和身体成分的关系。次要目的是研究这种关联是否受社会人口因素、孕间间隔和睡眠的影响。本研究是 INTER-ACT 电子健康支持生活方式试验的二次分析。如果女性在下一次妊娠时有心理健康测量值，并且在产后 6 周和下一次妊娠开始时有心理健康测量值（= 276），则符合条件。我们使用单变量分析来评估心理健康状况的差异，并进行回归分析，以评估其与下一次妊娠开始时的孕前 BMI 和身体成分的关系。我们的研究结果表明，从产后 6 周到下一次妊娠开始，焦虑和抑郁症状有统计学意义的增加（sSTAI-6≥40：增加 13%，=≤0.001；GMDS≥13：增加 9%，=0.01）。在产后 6 周时没有焦虑的女性中，超过三分之一（39%）在下一次妊娠开始时出现焦虑（=≤0.001）。回归分析显示，下一次妊娠开始时的综合应对能力（SOC-13）与女性的孕前 BMI 和体脂百分比独立相关。我们认为，制定孕前生活方式干预措施可能具有附加价值，这些措施既关注体重减轻，又关注理解、管理和赋予压力事件意义（综合应对能力），从而优化女性的孕前健康。
