Bernatoniene Jurga, Sciupokas Arunas, Kopustinskiene Dalia Marija, Petrikonis Kestutis
Department of Drug Technology and Social Pharmacy, Faculty of Pharmacy, Medical Academy, Lithuanian University of Health Sciences, Sukileliu pr. 13, LT-50161 Kaunas, Lithuania.
Institute of Pharmaceutical Technologies, Faculty of Pharmacy, Medical Academy, Lithuanian University of Health Sciences, Sukileliu pr. 13, LT-50161 Kaunas, Lithuania.
Pharmaceutics. 2023 Jun 23;15(7):1799. doi: 10.3390/pharmaceutics15071799.
Neuropathic pain is a debilitating condition characterized by abnormal signaling within the nervous system, resulting in persistent and often intense sensations of pain. It can arise from various causes, including traumatic nerve injury, neuropathy, and certain diseases. We present an overview of current and emerging pharmacotherapies for neuropathic pain, focusing on novel drug targets and potential therapeutic agents. Current pharmacotherapies, including tricyclic antidepressants, gabapentinoids, and serotonin norepinephrine re-uptake inhibitors, are discussed, as are emerging treatments, such as ambroxol, cannabidiol, and N-acetyl-L-cysteine. Additionally, the article highlights the need for further research in this field to identify new targets and develop more effective and targeted therapies for neuropathic pain management.
神经性疼痛是一种使人衰弱的病症，其特征是神经系统内的信号异常，导致持续且往往强烈的疼痛感。它可能由多种原因引起，包括外伤性神经损伤、神经病变和某些疾病。我们概述了目前用于神经性疼痛的药物疗法以及正在出现的药物疗法，重点关注新的药物靶点和潜在的治疗药物。讨论了目前的药物疗法，包括三环类抗抑郁药、加巴喷丁类药物和5-羟色胺去甲肾上腺素再摄取抑制剂，以及正在出现的治疗方法，如氨溴索、大麻二酚和N-乙酰-L-半胱氨酸。此外，本文强调了该领域进一步研究的必要性，以确定新的靶点，并开发出更有效、更具针对性的神经性疼痛管理疗法。
