National Blood Centre, Italian National Institute of Health, 00161 Rome, Italy.
Viruses. 2023 Jul 13;15(7):1543. doi: 10.3390/v15071543.
This review is focused on the use of hyperimmune globulin therapy to treat some infectious diseases of viral or bacterial origin. Despite the introduction of antibiotics and vaccines, plasma immunoglobulin therapy from whole blood donation can still play a key role. These treatments provide passive transfer of high-titer antibodies that either reduces the risk or the severity of the infection and offer immediate but short-term protection against specific diseases. Antibody preparations derived from immunized human donors are commonly used for the prophylaxis and treatment of rabies, hepatitis A and B viruses, varicella-zoster virus, and pneumonia caused by respiratory syncytial virus, , . The use of hyperimmune globulin therapy is a promising challenge, especially for the treatment of emerging viral infections for which there are no specific therapies or licensed vaccines.
这篇综述主要关注的是使用免疫球蛋白疗法来治疗一些病毒性或细菌性传染病。尽管抗生素和疫苗已经问世，但来自全血捐献的血浆免疫球蛋白疗法仍能发挥关键作用。这些治疗方法提供了高滴度抗体的被动转移，从而降低了感染的风险或严重程度，并对特定疾病提供了即时但短期的保护。从免疫供体中获得的抗体制剂通常用于预防和治疗狂犬病、甲型和乙型肝炎病毒、水痘-带状疱疹病毒以及由呼吸道合胞病毒引起的肺炎，。免疫球蛋白疗法的应用是一个有前途的挑战，特别是对于治疗新兴的病毒感染，这些感染目前没有特定的治疗方法或许可的疫苗。
