Pediatric Unit, Meyer Children's Hospital IRCCS, Viale Pieraccini 24, 50139 Florence, Italy.
Department of NEUROFARBA, University of Florence, Viale Pieraccini 24, 50139 Florence, Italy.
Viruses. 2023 Jul 15;15(7):1554. doi: 10.3390/v15071554.
The Coronavirus disease 2019 (COVID-19) and multisystem inflammatory syndrome in children (MIS-C) have been variably associated with thromboembolic events (TEs) in children. The aim of our study was to assess the prevalence of TEs in children hospitalized during a five-year period in a tertiary pediatric hospital, particularly in patients with COVID-19 and MIS-C. Overall, 38 patients were discharged with the diagnosis of TE: 20 in the pre-pandemic and 18 in the pandemic period. The prevalence of TEs was the same (0.08%) in the pre-pandemic and pandemic periods. The occurrence of TEs was higher in patients with COVID-19 or MIS-C (6/517, 1.16%) when compared to children without these conditions in the pandemic and in the pre-pandemic periods. The prevalence of TEs in children with MIS-C was significantly higher than the prevalence in patients with COVID-19. Five out of six of the patients with COVID-19 or MIS-C developing a TE had at least one predisposing factor to thrombosis. In conclusion, our study shows an increased prevalence of TEs in children hospitalized with COVID-19 or MIS-C, if compared to children without COVID-19 or MIS-C in the pandemic period and in the pre-pandemic period. The prevalence of TEs was significantly higher in patients with MIS-C.
2019 年冠状病毒病（COVID-19）和儿童多系统炎症综合征（MIS-C）与儿童的血栓栓塞事件（TEs）有不同程度的关联。我们的研究目的是评估在一家三级儿科医院住院的儿童在五年期间 TEs 的发生率，特别是在 COVID-19 和 MIS-C 患者中。总体而言，有 38 名患者出院时被诊断为 TE：20 名在大流行前，18 名在大流行期间。在大流行前和大流行期间，TEs 的发生率相同（0.08%）。与大流行期间和大流行前无这些情况的儿童相比，COVID-19 或 MIS-C 患者中 TE 的发生率更高（517 例中有 6 例，1.16%）。MIS-C 患儿中 TE 的发生率明显高于 COVID-19 患儿。COVID-19 或 MIS-C 发生 TE 的 6 例患者中，有 5 例至少有一个血栓形成的易患因素。总之，与大流行期间和大流行前无 COVID-19 或 MIS-C 的儿童相比，我们的研究表明 COVID-19 或 MIS-C 住院儿童 TEs 的发生率增加。在 COVID-19 或 MIS-C 患者中，TEs 的发生率在 MIS-C 患者中明显更高。
