Epinephrine, norepinephrine, and isoproterenol dose-outflow facility response relationships in cynomolgus monkey eyes with and without ciliary muscle retrodisplacement.

Intracameral slowly mixed bolus doses of 10 micrograms of 1-epinephrine or 1-norepinephrine bitartrate significantly increased total outflow facility by similar percentages in ciliary muscle disinserted and non-disinserted living cynomolgus monkey eyes (approximately 20% for epinephrine, 30% for norepinephrine); smaller or larger bolus doses (0.1, 1, 50 micrograms) either had no effect or tended to decrease facility. Bolus doses of dl-isoproterenol sulphate (0.1, 0.2, 10, 50 micrograms) or 1-isoproterenol hydrochloride (0.1, 1, 10 micrograms) had no effect in either type of eye. Rapidly mixed relatively maintained intracameral concentrations of dl(0.1, 1 micrograms/ml)- or l(0.1, 1, 10 micrograms/ml)-isoproterenol had no effect in surgically untouched eyes. All catecholamine solutions were stable under the experimental conditions.