Kaufman P L
Curr Eye Res. 1985 Aug;4(8):877-83. doi: 10.3109/02713688509095255.
Total outflow facility was measured by two-level constant pressure anterior chamber perfusion in surgically untouched vervet monkeys receiving intracameral infusions of mock aqueous humor without or with isoproterenol. Bolus dl-isoproterenol sulfate doses of 1 to 10 micrograms, corresponding respectively to initial intracameral base concentrations of 2 X 10(-5) M and 2 X 10(-4) M, increased facility 30-50%; higher and lower bolus doses were ineffective, as were 0.1 and 1 g doses of 1-isoproterenol hydrochloride (4 X 10(-6) M and 4 X 10(-5) M base). Relatively maintained intracameral dl-isoproterenol concentrations of 2 X 10(-7) M and 2 X 10(-6) M or l-isoproterenol concentrations of 4 X 10(-7) M to 4 X 10(-5) M did not significantly increase facility, although there was great variability with the latter agent. Possible reasons for species, investigator, technique, and dosage-associated differences in results are discussed.
在接受前房内注入无异丙肾上腺素或含异丙肾上腺素的模拟房水的未手术处理的黑长尾猴中，通过两级恒压前房灌注法测量总流出率。剂量为1至10微克的硫酸消旋异丙肾上腺素推注量，分别对应于前房内初始基础浓度为2×10⁻⁵M和2×10⁻⁴M，使流出率增加30 - 50%；更高和更低的推注剂量无效，0.1克和1克剂量的盐酸异丙肾上腺素（碱基浓度为4×10⁻⁶M和4×10⁻⁵M）也无效。相对维持在前房内的消旋异丙肾上腺素浓度为2×10⁻⁷M和2×10⁻⁶M，或左旋异丙肾上腺素浓度为4×10⁻⁷M至4×10⁻⁵M时，虽然后者存在很大变异性，但流出率并未显著增加。文中讨论了物种、研究者、技术以及剂量相关的结果差异的可能原因。
