Medical Microbiology and Immunology, University of Toledo College of Medicine and Life Sciences, Toledo, OH 43614, USA.
Physiology and Pharmacology, University of Toledo College of Medicine and Life Sciences, Toledo, OH 43614, USA.
Viruses. 2023 Jul 20;15(7):1579. doi: 10.3390/v15071579.
Inflammatory responses during virus infection differentially impact the host. Managing inflammatory responses is essential in controlling viral infection and related diseases. Recently, we identified a cellular anti-inflammatory mechanism, RIKA (Repression of IRF3-mediated inhibition of NF-κB activity), which controls viral inflammation and pathogenesis. The RIKA function of IRF3 may be explored further in other inflammatory diseases beyond viral infection.
病毒感染期间的炎症反应会对宿主产生不同的影响。控制炎症反应对于控制病毒感染和相关疾病至关重要。最近，我们发现了一种细胞抗炎机制 RIKA（抑制 IRF3 介导的 NF-κB 活性的抑制作用），它可以控制病毒炎症和发病机制。IRF3 的 RIKA 功能可能在病毒感染以外的其他炎症性疾病中得到进一步探索。
