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对于因酒精中毒前往急诊科就诊的年轻人,谁能从简短动机干预中获益:一项潜在类别调节分析。

Who benefits from brief motivational intervention among young adults presenting to the emergency department with alcohol intoxication: A latent-class moderation analysis.

作者信息

Gaume Jacques, Blanc Stéphanie, Magill Molly, McCambridge Jim, Bertholet Nicolas, Hugli Olivier, Daeppen Jean-Bernard

机构信息

Department of Psychiatry - Addiction Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.

Center for Alcohol and Addiction Studies, Brown University School of Public Health, Providence, Rhode Island, USA.

出版信息

Alcohol Clin Exp Res (Hoboken). 2023 Aug;47(8):1614-1623. doi: 10.1111/acer.15128. Epub 2023 Jul 29.

Abstract

BACKGROUND

Research has not identified which patients optimally benefit from brief Motivational Interviewing (bMI) for heavy drinking when delivered to young adults in the Emergency Department (ED).

METHODS

We conducted secondary analyses of data from a randomized controlled trial in which 344 young adults (18-35 years) presenting to the ED with alcohol intoxication received either bMI or Brief Advice (BA, control group). We used Latent Class Analysis to derive participants' profiles from baseline characteristics (i.e., sex, age, severity of alcohol use disorder, attribution of ED admission to alcohol use, importance, and confidence to change, cognitive discrepancy, anxiety, depression, and trait reactance). We then conducted a moderation analysis to assess the number of heavy drinking days at short-term (1-month) and long-term (12-month) follow-up using negative binomial regressions with interactions between the intervention and derived classes.

RESULTS

Fit statistics indicated that a 4-class solution best fit the data. Class 3 (high severity, importance and discrepancy, and low confidence and anxiety) benefitted more from bMI than BA at short- and long-term follow-up than Class 1 (younger; lowest severity, importance, discrepancy, reactance, anxiety and depression, and highest confidence). Class 2 (older; highest severity, importance, discrepancy, reactance, anxiety and depression, and lowest confidence) also benefitted more from bMI than BA than did Class 1 at short-term follow-up. In these significant contrasts, Class 1 benefitted more from BA than bMI. There were no significant interactions involving Class 4 (more likely to be women; low severity; high levels of anxiety, depression, and reactance).

CONCLUSIONS

This study identified the patient profiles that benefitted more from bMI than BA among nontreatment-seeking young adults who present intoxicated to the ED. The findings have implications for intervention design and argue for the importance of research aimed at developing intervention content tailored to patient profiles.

摘要

背景

研究尚未确定在急诊科(ED)对年轻成年人进行简短动机性访谈(bMI)以解决重度饮酒问题时,哪些患者能最佳受益。

方法

我们对一项随机对照试验的数据进行了二次分析,该试验中344名因酒精中毒前往急诊科的年轻成年人(18 - 35岁)接受了bMI或简短建议(BA,对照组)。我们使用潜在类别分析从基线特征(即性别、年龄、酒精使用障碍的严重程度、因饮酒导致急诊科就诊的归因、改变的重要性和信心、认知差异、焦虑、抑郁和特质反应性)中得出参与者的概况。然后,我们进行了调节分析,使用负二项回归并结合干预与派生类别之间的相互作用,来评估短期(1个月)和长期(12个月)随访时的重度饮酒天数。

结果

拟合统计表明,四类解决方案最适合数据。在短期和长期随访中,第3类(高严重程度、重要性和差异,低信心和焦虑)比第1类(更年轻;最低严重程度、重要性、差异、反应性、焦虑和抑郁,最高信心)从bMI中获益更多。在短期随访中,第2类(年龄较大;最高严重程度、重要性、差异、反应性、焦虑和抑郁,最低信心)也比第1类从bMI中获益更多。在这些显著对比中,第1类从BA中获益比从bMI中更多。没有涉及第4类(更可能是女性;低严重程度;高焦虑、抑郁和反应性水平)的显著相互作用。

结论

本研究确定了在因醉酒前往急诊科的非寻求治疗的年轻成年人中,比BA更能从bMI中获益的患者概况。这些发现对干预设计具有启示意义,并表明针对患者概况开发干预内容的研究很重要。

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