血清硒和硒蛋白 P 与 2 型糖尿病和高血压在柏林老龄化研究 II 中的性别特异性关联。
Sex-specific associations of serum selenium and selenoprotein P with type 2 diabetes mellitus and hypertension in the Berlin Aging Study II.
机构信息
Institute for Experimental Endocrinology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Max Rubner Center (MRC) for Cardiovascular Metabolic Renal Research, D-10115, Berlin, Germany.
Department of Endocrinology and Metabolic Diseases (including Division of Lipid Metabolism), Biology of Aging Working Group, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, And Berlin Institute of Health (BIH), Berlin, Germany.
出版信息
Redox Biol. 2023 Sep;65:102823. doi: 10.1016/j.redox.2023.102823. Epub 2023 Jul 23.
BACKGROUND
Selenium is essential for expression and proper function of a set of redox active selenoproteins implicated in aging-relevant diseases, e.g. type 2 diabetes mellitus (T2D) and hypertension. However, data in cohorts of older adults, particularly with respect to different Se biomarkers and sex-specific analyses are sparse.
OBJECTIVE
To assess associations of serum Se and selenoprotein P (SELENOP) concentrations with T2D and hypertension in a cohort of older females and males.
METHODS
This study included 1500 participants from the Berlin Aging Study II. Diagnosis of T2D was made in case of antidiabetic medication, self-reported T2D, or laboratory parameters. Diagnosis of hypertension was based on self-report, blood pressure measurement, or anti-hypertensive medication. Se was measured by spectroscopy, and SELENOP by ELISA. Multiple adjusted regression models quantified dose-dependent associations.
RESULTS
Participants had a median(IQR) age of 68 (65,71) years, and 767 (51%) were women. 191 (13%) participants had T2D and 1126 (75%) had hypertension. Se and SELENOP correlated significantly (r = 0.59, p < 0.001), and were elevated in those with self-reported Se supplementation. Serum Se and SELENOP were not associated with T2D in the whole cohort. In men, SELENOP was positively associated with T2D, OR (95%CI) for one mg/L increase in SELENOP was 1.22 (1.00,1.48). Se was non-linearly associated with hypertension, comparing to the lowest quartile (Q1), and participants with higher Se levels (Q3) had a lower OR (95%CI) of 0.66 (0.45,0.96), which was specific for men. SELENOP positively associated with hypertension, and OR (95%CI) per one mg/L increase was 1.15 (1.01,1.32).
CONCLUSIONS
The data suggest a sex-specific interrelationship of Se status with T2D and hypertension, with apparent biomarker-specific associations.
背景
硒对于一组与衰老相关疾病（如 2 型糖尿病（T2D）和高血压）相关的氧化还原活性硒蛋白的表达和正常功能至关重要。然而，在老年人队列中，特别是关于不同的 Se 生物标志物和性别特异性分析的数据仍然很少。
目的
评估血清 Se 和硒蛋白 P（SELENOP）浓度与老年女性和男性中 T2D 和高血压的关系。
方法
这项研究纳入了柏林衰老研究 II 中的 1500 名参与者。T2D 的诊断标准为服用降糖药物、自我报告 T2D 或实验室参数。高血压的诊断基于自我报告、血压测量或抗高血压药物。Se 通过光谱法测量，SELENOP 通过 ELISA 测量。多因素调整回归模型定量了剂量依赖性关联。
结果
参与者的中位（IQR）年龄为 68（65，71）岁，767 名（51%）为女性。191 名（13%）参与者患有 T2D，1126 名（75%）患有高血压。血清 Se 和 SELENOP 显著相关（r=0.59，p<0.001），且在自我报告 Se 补充的参与者中升高。在整个队列中，血清 Se 和 SELENOP 与 T2D 无关。在男性中，SELENOP 与 T2D 呈正相关，SELENOP 每增加 1mg/L，OR（95%CI）为 1.22（1.00，1.48）。Se 与高血压呈非线性相关，与最低四分位（Q1）相比，Se 水平较高（Q3）的参与者的 OR（95%CI）为 0.66（0.45，0.96），这一结果仅在男性中存在。SELENOP 与高血压呈正相关，每增加 1mg/L，OR（95%CI）为 1.15（1.01，1.32）。
结论
数据表明，Se 状态与 T2D 和高血压之间存在性别特异性的相互关系，且与明显的生物标志物特异性相关。
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