Halmy L, Walter J, Nyakas C
Acta Physiol Hung. 1986;68(1):5-9.
The neurotoxin kainic acid was injected bilaterally into the ventromedial hypothalamus of female rats in doses of 100 or 200 ng. The injections produced microlesions which led to progressive body weight gain and fat deposition in dose dependent manner. The histological examination revealed that the lesions were mainly located in the region between the ventromedial hypothalamic nuclei and the fornix.
将神经毒素海藻酸以100或200纳克的剂量双侧注射到雌性大鼠的腹内侧下丘脑。注射产生了微损伤，导致体重逐渐增加和脂肪沉积，且呈剂量依赖性。组织学检查显示，损伤主要位于腹内侧下丘脑核与穹窿之间的区域。
