Nikolov Y T, Dimitrov O A, Kabaivanova S D, Moskova V V, Ivanova V L
Acta Physiol Pharmacol Bulg. 1986;12(1):57-61.
The article is a study of the specific binding of 3H-17, beta-estradiol to cytosol receptors in the liver of female, sexually mature albino rats: sham-operated, ovariectomized and treated after the ovariectomy with 17-beta-estradiol (in doses of 20 micrograms/100 g body weight for 11 days). The binding of the labelled hormone in the liver cytosol isolated from ovariectomized rats is considerably reduced compared with the sham-operated animals. In the cytosol from the liver of the estradiol-treated rats the formation of a hormone-receptor complex is substantially increased compared with the ovariectomized animals. It is assumed that the formation of estradiol-receptor complexes in the liver depends on the concentration of the cytosol receptors, which is determined by the concentration of oestrogens in the blood.
本文是一项关于3H-17β-雌二醇与雌性性成熟白化大鼠肝脏胞质溶胶受体特异性结合的研究：假手术组、卵巢切除组以及卵巢切除后用17β-雌二醇治疗的组（剂量为20微克/100克体重，持续11天）。与假手术动物相比，从卵巢切除大鼠分离的肝脏胞质溶胶中标记激素的结合显著减少。与卵巢切除动物相比，在经雌二醇处理的大鼠肝脏胞质溶胶中，激素-受体复合物的形成显著增加。据推测，肝脏中雌二醇-受体复合物的形成取决于胞质溶胶受体的浓度，而胞质溶胶受体的浓度由血液中雌激素的浓度决定。
