Indian Council of Medical Research - National Institute for Research in Reproductive and Child Health (ICMR-NIRRCH), Mumbai 400012, India.
Indian Council of Medical Research - National Institute for Research in Reproductive and Child Health (ICMR-NIRRCH), Mumbai 400012, India.
Life Sci. 2023 Sep 15;329:121980. doi: 10.1016/j.lfs.2023.121980. Epub 2023 Jul 27.
Breast Cancer has the highest burden in females worldwide and is predicted to increase by many folds with increasing lifestyle related risk factors, genetic mutations, and an aging population. The Hippo signalling and Wnt signalling pathways were identified as important signal transducers involved in maintaining organ development, tissue homeostasis, cell proliferation and apoptosis. microRNAs are short nucleotide sequences which act as regulatory components driving signal transductions in most cancers and can serve as both diagnostic and prognostic markers. Several reports have implicated that deregulated Hippo as well as Wnt signalling mediated by miRNAs together drive tumorigenesis, metastases and chemoresistance in breast cancer. Recent evidences on a crosstalk between Hippo and Wnt components elucidated how these pathways might be synchronized to have overlapping functions to promote tumorigenesis. Since miRNAs are demonstrated to target most of the components in both the pathways, in this review, we talk about the crosstalk between Hippo and Wnt signalling pathways and the potential microRNAs that might regulate the interplay between the two pathways in breast cancer, which has not been explored earlier.
乳腺癌是全球女性中负担最重的疾病，预计随着与生活方式相关的风险因素、基因突变和人口老龄化的增加，乳腺癌的发病率将呈数倍增长。Hippo 信号通路和 Wnt 信号通路被确定为参与维持器官发育、组织内稳态、细胞增殖和凋亡的重要信号转导因子。microRNAs 是短核苷酸序列，作为调节成分在大多数癌症中驱动信号转导，可作为诊断和预后标志物。有几项报道表明，miRNAs 介导的失调的 Hippo 以及 Wnt 信号通路共同驱动乳腺癌的肿瘤发生、转移和化疗耐药。最近关于 Hippo 和 Wnt 成分之间相互作用的证据阐明了这些通路如何同步发挥重叠功能以促进肿瘤发生。由于 miRNA 被证明可以靶向这两个通路中的大多数成分，因此在这篇综述中，我们讨论了 Hippo 和 Wnt 信号通路之间的相互作用，以及可能在乳腺癌中调节这两个通路相互作用的潜在 microRNAs，这在以前尚未得到探索。
