Pia H W
Acta Neurochir (Wien). 1986;82(1-2):1-6. doi: 10.1007/BF01456312.
Following the research of Giessen Neurosurgery on primary and secondary lesions of the hypothalamo-pituitary system and the brainstem over a period of more than 30 years, cerebral failure and death does not represent a uniform syndrome but consists of several, well characterized syndromes of irreversible hypothalamo-pituitary, mesencephalic and bulbar failure. The specific syndromes are described in detail. The diagnosis is based on establishing complete irreversible damage of specific vital basal functions such as hypothalamo-pituitary transmission, water- and electrolyte metabolism, temperature regulation, circulation and respiration. The common feature of all types is the irreversible break-down of the complex central neurogenous and/or neurohumoral regulatory system. The permanent and irreversible loss of central regulation and modulation means at the same time the complete cessation of the specific human cortical function, the death of the whole brain. Only in bulbar failure with primary irreversible cessation of respiration artificial respiration can maintain the autonomous functions of the heart for a limited time. It is indicated when organ explantation is to be considered. Complete and irreversible isolated loss of cortical function abolishes the normal human life, but does not mean death of the remaining vegetating human being.
在吉森神经外科对下丘脑 - 垂体系统和脑干的原发性及继发性病变进行了30多年的研究之后，脑功能衰竭和死亡并非一种统一的综合征，而是由几种特征明确的、不可逆的下丘脑 - 垂体、中脑和延髓功能衰竭综合征组成。具体综合征将详细描述。诊断基于确定特定重要基础功能的完全不可逆损害，如下丘脑 - 垂体传递、水和电解质代谢、体温调节、循环和呼吸。所有类型的共同特征是复杂的中枢神经源性和/或神经体液调节系统的不可逆崩溃。中枢调节和调制的永久性和不可逆丧失同时意味着特定人类皮质功能的完全停止，即全脑死亡。只有在延髓衰竭且原发性呼吸不可逆停止的情况下，人工呼吸才能在有限时间内维持心脏的自主功能。当考虑进行器官移植时才会使用。皮质功能的完全和不可逆孤立丧失会消除正常的人类生活，但并不意味着剩余植物人状态的人的死亡。
