Centro de Química Estrutural, Institute of Molecular Sciences, Faculdade de Ciências, Universidade de Lisboa, 1749-016, Lisboa, Portugal.
Carbohydr Res. 2023 Oct;532:108889. doi: 10.1016/j.carres.2023.108889. Epub 2023 Jul 17.
Nucleosides have gained significant attention since the discovery of the structure of DNA. Nucleoside analogues may be synthesized through multiple synthetic pathways, however the N-glycosylation of a nucleobase is the most common method. Amongst the different classical N-glycosylation methodologies, the Vorbrüggen glycosylation is the most popular method. This review focuses on the synthesis and therapeutic applications of several FDA approved nucleoside analogues as antiviral and anticancer agents. Moreover, this review also focuses on the potential of these compounds as new antibacterial and anti-Alzheimer's disease agents, offering an overview of the most recent research in these fields.
自从发现 DNA 的结构以来，核苷引起了人们的极大关注。核苷类似物可以通过多种合成途径合成，但是碱基的 N-糖基化是最常见的方法。在不同的经典 N-糖基化方法中，Vorbrüggen 糖苷化是最常用的方法。本文综述了几种已被 FDA 批准的核苷类似物作为抗病毒和抗癌药物的合成和治疗应用。此外，本文还重点介绍了这些化合物作为新型抗菌和抗阿尔茨海默病药物的潜力，概述了这些领域的最新研究进展。
