Hammouda Mohamed M, Elattar Khaled M, Rashed Marwa M, Osman Amany M A
Department of Chemistry, College of Science and Humanities in Al-Kharj, Prince Sattam Bin Abdulaziz University, Al-Kharj 11942, Saudi Arabia; Chemistry Department, Faculty of Science, Mansoura University, El-Gomhoria Street, Mansoura 35516, Egypt.
Unit of Genetic Engineering and Biotechnology, Faculty of Science, Mansoura University, El-Gomhoria Street, Mansoura 35516, Egypt.
Steroids. 2023 Nov;199:109287. doi: 10.1016/j.steroids.2023.109287. Epub 2023 Jul 28.
Reports on structural modification of heterosteroids through various reactions, and developed synthetic routes have considerably increased over the last decade. The present review encompasses the applicable approaches dealing with the utility of reactive moieties in various steroids for the synthesis of fused bicyclic pyridines, and binary bicyclic pyridines all over the years. The different sections include the synthesis of steroids-fused, and binary quinolines, pyridopyrimidines, imidazopyridines, spirocyclic imidazopyridines, pyrazolopyridines, thienopyridines, pyridinyl-thiazoles, and tetrazolopyridine hybrids, as well as, the diverse biological applications of these heterocyclic steroids. The researchers' interest was principally focused on investigating the flexibility of synthetic strategies for various derivatives of natural steroids and building proposals based on heterocyclic steroids for drug discovery, biological assessments, and synthetic applications.
在过去十年中，关于通过各种反应对杂甾体进行结构修饰以及所开发的合成路线的报道大幅增加。本综述涵盖了多年来处理各种甾体中反应性部分用于合成稠合双环吡啶和二元双环吡啶的适用方法。不同章节包括甾体稠合喹啉、二元喹啉、吡啶并嘧啶、咪唑并吡啶、螺环咪唑并吡啶、吡唑并吡啶、噻吩并吡啶、吡啶基噻唑和四唑并吡啶杂化物的合成，以及这些杂环甾体的各种生物学应用。研究人员的兴趣主要集中在研究天然甾体各种衍生物的合成策略的灵活性，并基于杂环甾体提出用于药物发现、生物学评估和合成应用的建议。
