较小的海马体体积与癌症儿童和接受简短新颖武术为基础的干预后的癌症幸存者创伤后应激症状减少相关。
Smaller Hippocampal Volume Is Associated With Reduced Posttraumatic Stress Symptoms in Children With Cancer and Survivors Following a Brief Novel Martial Arts-Based Intervention.
机构信息
Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI 48201, USA.
Department of Pharmacy Practice, Wayne State University, Detroit, MI 48201, USA.
出版信息
Arch Clin Neuropsychol. 2024 Feb 19;39(2):167-174. doi: 10.1093/arclin/acad056.
PURPOSE
Children with cancer and survivors frequently report posttraumatic stress symptoms (PTSS), which are associated with volumetric changes in stress-sensitive brain regions, including the hippocampus.
METHODS
We examined the impact of a novel, 4-week martial-arts-based meditative intervention on cancer-related PTSS in 18 pediatric patients and survivors and whether baseline hippocampal volumes correlate with PTSS severity and/or PTSS changes over time.
RESULTS
Overall, PTSS did not significantly change from baseline to post-intervention. Smaller hippocampal volume was correlated with more severe re-experiencing PTSS at baseline, and greater reductions in PTSS post-intervention.
CONCLUSIONS
Together, hippocampal volume may be a biomarker of PTSS severity and intervention response. Identifying hippocampal volume as a potential biomarker for PTSS severity and intervention response may allow for more informed psychosocial treatments.
目的
癌症患儿和幸存者经常报告创伤后应激症状（PTSS），这与应激敏感脑区（包括海马体）的体积变化有关。
方法
我们研究了一项新的、为期 4 周的武术冥想干预对 18 名儿科癌症患者和幸存者相关 PTSD 的影响，以及基线海马体体积是否与 PTSD 严重程度和/或随时间的 PTSD 变化相关。
结果
总体而言，从基线到干预后，PTSD 没有显著变化。基线时海马体体积较小与再体验 PTSD 严重程度相关，干预后 PTSD 减轻程度更大。
结论
海马体体积可能是 PTSD 严重程度和干预反应的生物标志物。将海马体体积确定为 PTSD 严重程度和干预反应的潜在生物标志物，可能有助于制定更明智的心理社会治疗方法。
Zotero 插件