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使用 HbA1c 或 HbA1c/糖化白蛋白估算平均红细胞年龄，评估贫血严重程度。

Estimation of mean erythrocyte age using HbA1c or HbA1c/glycated albumin for evaluation of anemia severity.

机构信息

Department of Internal Medicine, Hakuhokai Central Hospital, Amagasaki, Japan.

Research Team for Neuroimaging, Tokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo, Japan.

出版信息

J Clin Lab Anal. 2023 Jul;37(13-14):e24947. doi: 10.1002/jcla.24947. Epub 2023 Jul 30.

DOI:10.1002/jcla.24947
PMID:37518970
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10492451/
Abstract

BACKGROUND

Hemoglobin A1c (HbA1c) levels are low in patients with hemolytic anemia, as HbA1c reflects mean erythrocyte age (M ). Erythrocyte creatine (EC) is a hemolytic indicator that also reflects M . We previously reported an equation for estimating M using EC (EC-M ).

AIMS

In this study, EC-M was compared to the HbA1c level expressed in the International Federation of Clinical Chemistry and Laboratory Medicine units (iA1c) and to the iA1c/glycated albumin (GA) ratio to estimate M .

METHODS

This study included 238 subjects, including patients with hemolytic anemia and/or type 2 diabetes mellitus (T2DM).

RESULTS

In non-diabetic individuals, both iA1c and iA1c/GA showed a strong positive correlation with EC-M (p < 0.0001). The equations to estimate iA1c-M and iA1c/GA-M derived from the regression equations between EC-M and iA1c, and EC-M and iA1c/GA in nondiabetic individuals were 1.45 × iA1c and 20.0 × iA1c/GA, respectively. iA1c-MRBC and iA1c/GA-MRBC in non-diabetic individuals without hemolytic anemia were 57.6 ± 4.0 and 57.1 ± 6.4 days, respectively, and iA1c/GA-MRBC in T2DM patients without hemolytic anemia was 56.0 ± 8.8 days.; no significant difference was seen in the comparisons.

CONCLUSIONS

The M can be estimated using iA1c or iA1c/GA in non-diabetic individuals, and iA1c/GA in T2DM patients.

摘要

背景

血红蛋白 A1c（HbA1c）水平在溶血性贫血患者中较低，因为 HbA1c 反映平均红细胞年龄（M）。红细胞肌酸（EC）是一种溶血指标，也反映 M。我们之前报道了一种使用 EC 估算 M 的方程（EC-M）。

目的

本研究比较了 EC-M 与国际临床化学和实验室医学联合会单位（iA1c）表示的 HbA1c 水平以及 iA1c/糖化白蛋白（GA）比值来估计 M。

方法

本研究纳入了 238 例患者，包括溶血性贫血和/或 2 型糖尿病（T2DM）患者。

结果

在非糖尿病个体中，iA1c 和 iA1c/GA 与 EC-M 均呈强正相关（p<0.0001）。从非糖尿病个体的 EC-M 与 iA1c 及 EC-M 与 iA1c/GA 的回归方程中得出的估算 iA1c-M 和 iA1c/GA-M 的方程分别为 1.45×iA1c 和 20.0×iA1c/GA。非溶血性贫血的非糖尿病个体的 iA1c-MRBC 和 iA1c/GA-MRBC 分别为 57.6±4.0 和 57.1±6.4 天，非溶血性贫血的 T2DM 患者的 iA1c/GA-MRBC 为 56.0±8.8 天；这些比较没有显著差异。

结论

在非糖尿病个体中可以使用 iA1c 或 iA1c/GA 估算 M，在 T2DM 患者中可以使用 iA1c/GA。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35bc/10492451/efbd607f688d/JCLA-37-e24947-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35bc/10492451/865d2b5d92a8/JCLA-37-e24947-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35bc/10492451/9087c83cafe7/JCLA-37-e24947-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35bc/10492451/efbd607f688d/JCLA-37-e24947-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35bc/10492451/865d2b5d92a8/JCLA-37-e24947-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35bc/10492451/9087c83cafe7/JCLA-37-e24947-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35bc/10492451/efbd607f688d/JCLA-37-e24947-g001.jpg

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Recent Updates and Advances in the Use of Glycated Albumin for the Diagnosis and Monitoring of Diabetes and Renal, Cerebro- and Cardio-Metabolic Diseases.糖化白蛋白在糖尿病及肾、脑和心血管代谢疾病诊断与监测中的最新进展
J Clin Med. 2020 Nov 11;9(11):3634. doi: 10.3390/jcm9113634.
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