载钛介孔纳米粒子对 MCF-7 和 MDA-MB-231 乳腺癌细胞系的细胞毒性和 DNA 结合能力。
Cytotoxic and DNA-binding Capacity of Titanocene Functionalized Mesoporous Nanoparticles in Breast Cancer Cell Lines MCF-7 and MDA-MB-231.
机构信息
COMET-NANO Group, Departamento de Biología y Geología, Física y Química Inorgánica, E.S.C.E.T., Universidad Rey Juan Carlos, Calle Tulipán s/n, Móstoles, E-28933, Madrid, Spain.
Department of Chemistry, Federal University of Agriculture, Makurdi, 970231, Nigeria.
出版信息
Curr Pharm Des. 2023;29(22):1791-1799. doi: 10.2174/1381612829666230727115356.
AIMS
The fight against cancer is an active research topic that combines several disciplines to find suitable agents to treat various tumours.
BACKGROUND
Following cisplatin, organometallic compounds, including titanocene derivatives, have been tested as antitumoral agents. However, key issues still need to be addressed in metallodrug chemotherapy relating to solubility, stability, and dosage. Mesoporous silica nanoparticles, being low toxic biocompatible materials with high loading capacity, are ideal candidates to overcome these problems.
OBJECTIVE
This study aimed to prepare and structurally characterize titanocene functionalized mesoporous silica nanoparticles and evaluate their cytotoxic activity against cancer cells.
METHODS
The preparation of titanocene functionalized mesoporous silica nanoparticles was achieved by synthetic protocols, involving either grafting or tethering. Characterization was carried out using standard techniques, FT-IR, XRD, XRF, TEM, and BET. The titanocene functionalized materials were studied as antitumoral agents in the breast cancer lines MCF-7 and MDA-MB-231.
RESULTS
The functionalized MSN showed promising antitumoral activity against cells lines MCF-7 and MDAMB- 231 up to 9 times more than titanocene alone.
CONCLUSION
This study reported the potential of titanocene-functionalized mesoporous silica nanoparticles in future chemotherapeutic actions.
目的
癌症的防治是一个多学科结合的研究课题，旨在寻找合适的药物来治疗各种肿瘤。
背景
继顺铂之后，人们已经测试了包括钛络合物衍生物在内的有机金属化合物作为抗肿瘤药物。然而，金属药物化疗在溶解度、稳定性和剂量方面仍存在一些关键问题需要解决。介孔硅纳米粒子作为一种低毒、生物相容性好、载药能力高的材料，是克服这些问题的理想候选材料。
目的
本研究旨在制备和结构表征功能化的钛络合物介孔硅纳米粒子，并评估其对癌细胞的细胞毒性活性。
方法
通过合成方案，包括接枝或键合，制备了功能化的钛络合物介孔硅纳米粒子。采用标准技术，如傅里叶变换红外光谱（FT-IR）、X 射线衍射（XRD）、X 射线荧光光谱（XRF）、透射电子显微镜（TEM）和 BET 对其进行了表征。研究了钛络合物功能材料作为乳腺癌细胞系 MCF-7 和 MDA-MB-231 的抗肿瘤剂。
结果
功能化的 MSN 对 MCF-7 和 MDA-MB-231 细胞系表现出良好的抗肿瘤活性，其活性比单独使用钛络合物高 9 倍。
结论
本研究报道了钛络合物功能化介孔硅纳米粒子在未来化疗中的潜力。
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